Nandrolone Decanoate and Load Increase Remodeling and Strength in Human Supraspinatus Bioartificial Tendons
| Autor: | Spero G. Karas, William E. Garrett, Melissa Marie Maloney, Albert J. Banes, Karl F. Bowman, Ioannis K. Triantafillopoulos |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Anabolism Physical Therapy Sports Therapy and Rehabilitation Anabolic Agents Bone remodeling Tendons Rotator Cuff 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Nandrolone Orthopedics and Sports Medicine Rotator cuff Aged Wound Healing 030109 nutrition & dietetics Bioartificial Organs Tissue Engineering business.industry 030229 sport sciences Middle Aged Actin cytoskeleton Biomechanical Phenomena Tendon Surgery medicine.anatomical_structure Endocrinology Nandrolone Decanoate Female Matrix Metalloproteinase 3 Bone Remodeling business Wound healing medicine.drug |
| Zdroj: | The American Journal of Sports Medicine. 32:934-943 |
| ISSN: | 1552-3365 0363-5465 |
| DOI: | 10.1177/0363546503261700 |
| Popis: | BackgroundTo date, no studies document the effect of anabolic steroids on rotator cuff tendons.Study DesignControlled laboratory study.HypothesisAnabolic steroids enhance remodeling and improve the biomechanical properties of bioartificially engineered human supraspinatus tendons.MethodsBioartificial tendons were treated with either nandrolone decanoate (nonload, steroid, n = 18), loading (load, nonsteroid, n = 18), or both (load, steroid, n = 18). A control group received no treatment (nonload, nonsteroid [NLNS], n = 18). Bioartificial tendons’ remodeling was assessed by daily scanning, cytoskeletal organization by staining, matrix metalloproteinase-3 levels by ELISA assay, and biomechanical properties by load-to-failure testing.ResultsThe load, steroid group showed the greatest remodeling and the best organized actin cytoskeleton. Matrix metallo-proteinase-3 levels in the load, steroid group were greater than those of the nonload, nonsteroid group (P < .05). Ultimate stress and ultimate strain in the load, steroid group were greater than those of the nonload, nonsteroid and nonload, steroid groups (P < .05). The strain energy density in the load, steroid group was greater when compared to other groups (P < .05).ConclusionsNandrolone decanoate and load acted synergistically to increase matrix remodeling and biomechanical properties of bioartificial tendons.Clinical RelevanceData suggest anabolic steroids may enhance production of bioartificial tendons and rotator cuff tendon healing in vitro. More research is necessary before such clinical use is recommended. |
| Databáze: | OpenAIRE |
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