CONCENTRATIONS OF PREGNANCY-SPECIFIC β1-GLYCOPROTEIN IN MATERNAL BLOOD IN NORMAL PREGNANCY AND IN INTRAUTERINE GROWTH RETARDATION
| Autor: | T. Chard, Y. B. Gordon, Diana Jeffrey, A. T. Letchworth, J.G. Grudzinskas |
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| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Placenta Diseases Pregnancy Trimester Third Birth weight Pregnancy Complications Cardiovascular Radioimmunoassay Normal pregnancy Maternal blood Pregnancy Birth Weight Humans Medicine Glycoproteins chemistry.chemical_classification Fetus Growth retardation business.industry Obstetrics Infant Newborn General Medicine Placental Insufficiency medicine.disease Fetal Diseases chemistry Placental Function Tests Hypertension Female business Glycoprotein |
| Zdroj: | The Lancet. 309:331-333 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(77)91135-7 |
| Popis: | A radioimmunoassay has been developed for pregnancy-specific beta 1-glycoprotein (S.P.1), a product of the human placenta. Circulating concentrations of S.P.1 were measured in 153 women in the third trimester of normal pregnancy and in 27 women who delivered children with birth-weight below the 10th centile of the normal range--i.e., with intrauterine growth regardation (I.U.G.R.). Concentrations of S.P.1 showed a skewed distribution and rose progressively to reach a plateau in the last four weeks of pregnancy. In over 70% of women with I.U.G.R. of the fetus, concentrations of S.P.1 were low. Measurement of serum-S.P.1 may provide a new index of fetal wellbeing. |
| Databáze: | OpenAIRE |
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