A Fermentation Product of Phytosterol Including Campestenone Reduces Body Fat Storage and Body Weight Gain in Mice
| Autor: | Takeshi Shimizu, Tadashi Nagashima, Rie Konno, Kunio Suzuki, Akihiko Kimura |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Medicine (miscellaneous) Biology Weight Gain Excretion Feces Mice chemistry.chemical_compound Internal medicine medicine Animals Body Fat Distribution Food science Triglycerides Analysis of Variance Mice Inbred ICR Nutrition and Dietetics Dose-Response Relationship Drug Triglyceride Phytosterol Phytosterols Lipid Metabolism medicine.disease Obesity Sterol Dose–response relationship Cholesterol Endocrinology Adipose Tissue Liver chemistry Fermentation Models Animal Body Composition medicine.symptom Weight gain Biomarkers |
| Zdroj: | Journal of Nutritional Science and Vitaminology. 53:63-67 |
| ISSN: | 1881-7742 0301-4800 |
| DOI: | 10.3177/jnsv.53.63 |
| Popis: | Anti-obesity effects of a fermentation product of phytosterols including campestenone in ICR mice were investigated. Five-week-old male ICR mice were fed by the pair-feeding method for 8 wk. Experimental feed was prepared by adding TO-001, a phytostenone mixture produced by fermentation of phytosterols using Nocardioides simplex, at 0.25, 0.5, 1.0, or 2.0% or no additive to a high fat diet (fat 20%). Mice fed a stock feed (fat 5.6%) ad libitum were used as the standard growth group. In animals fed the high fat diet, control (no added TO-001) mice showed a weight gain that was about 10% higher than for the standard growth group. TO-001 reduced body weight dose-dependently. Final body weights of 0.5% and 1.0% TO-001-fed mice were lowered by about 9% and those of 2.0% TO-00 I-fed mice by about 12% compared with the control mice. Visceral and subcutaneous fat weight in mice fed TO-001 was significantly lower than that in mice fed the control diet. The concentrations of serum triglyceride (TG) and total cholesterol (TC) were significantly lower in the 1.0% and/or 2.0% TO-001-fed mice. Furthermore, levels of liver TG and TC were decreased in the TO-001-fed group. Increase of total lipid excretion in the feces was dose dependent. No obvious abnormalities due to consumption of TO-001 were detected by a blood biochemical examination, clinical observations or necropsy. The results suggested that TO-001, a fermentation product of phytosterols, may be a promising component of dietetic functional foods. |
| Databáze: | OpenAIRE |
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