Prenatal, concurrent, and sex-specific associations between blood lead concentrations and IQ in preschool Canadian children
| Autor: | Tye E. Arbuckle, Michel Boivin, Nadine Forget-Dubois, Emmanuel Ouellet, William D. Fraser, Bruce P. Lanphear, Pierre Ayotte, Gina Muckle, Jean R. Séguin, Youssef Oulhote, Mireille Desrochers-Couture |
|---|---|
| Přispěvatelé: | Université de Montréal. Faculté de médecine. Département de psychiatrie et d'addictologie |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Canada medicine.medical_specialty Cord Canadian children Blood lead concentrations 010501 environmental sciences 01 natural sciences Young Adult 03 medical and health sciences Cognition 0302 clinical medicine Pregnancy Sex differences Humans Medicine lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science Intelligence Tests lcsh:GE1-350 Wechsler Preschool and Primary Scale of Intelligence Intelligence quotient business.industry Obstetrics Environmental Exposure Venous blood Middle Aged medicine.disease Lead Child Preschool Prenatal Exposure Delayed Effects Cord blood Cohort Female business 030217 neurology & neurosurgery |
| Zdroj: | Environment International, Vol 121, Iss, Pp 1235-1242 (2018) |
| ISSN: | 0160-4120 |
| Popis: | Background: Lead exposure predicts altered neurodevelopment and lower intelligence quotient (IQ) in children, but few studies have examined this association in children who have relatively low blood lead concentrations. Objectives: To test the associations between blood lead concentrations and cognitive function in Canadian preschoolers, with a possible moderation by sex. Methods: The data were gathered from 609 mother-child pairs from the Maternal–Infant Research on Environmental Chemicals (MIREC) Study. Lead was measured in umbilical and maternal blood, and in children's venous blood at age 3–4 years. Cognitive function was measured with the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) at 3–4 years. We tested the relationship between WPPSI-III scores and blood lead concentrations with multiple linear regression, adding child sex as a moderator. Results: Median blood lead concentrations for the mother at 1st trimester and 3rd trimester of pregnancy, and for cord and child blood were 0.60 μg/dL, 0.58 μg/dL, 0.79 μg/dL and 0.67 μg/dL, respectively. We found no association between cord blood lead concentrations and WPPSI-III scores in multivariable analyses. However, cord blood lead concentrations showed a negative association with Performance IQ in boys but not in girls (B = 3.44; SE = 1.62; 95% CI: 0.82, 5.98). No associations were found between WPPSI-III scores and prenatal maternal blood or concurrent child blood lead concentrations. Conclusions: Prenatal blood lead concentrations below 5 μg/dL were still associated with a decline in cognitive function in this Canadian cohort, but only for boys. Keywords: Blood lead concentrations, Sex differences, Intelligence quotient, Canadian children |
| Databáze: | OpenAIRE |
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