Validation of the Addenbrooke’s Cognitive Examination for Detecting Early Alzheimer’s Disease and Mild Vascular Dementia in a German Population
| Autor: | B. Greim, Gregor Domes, B. Krecklow, Sabine C. Herpertz, Panagiotis Alexopoulos, K. Nadler, U. Martens, Alexander Kurz |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Pathology Cognitive Neuroscience Alzheimer’s disease Vascular dementia German population Addenbrooke’s Cognitive Examination Mini-Mental State Examination Neuropsychological Tests Severity of Illness Index Alzheimer Disease Germany mental disorders medicine Humans Dementia Medical diagnosis Aged Aged 80 and over Mini–Mental State Examination Receiver operating characteristic medicine.diagnostic_test Dementia Vascular Cognitive disorder Reproducibility of Results Middle Aged medicine.disease Addenbrooke's cognitive examination ddc Psychiatry and Mental health Early Diagnosis Female Geriatrics and Gerontology Alzheimer's disease Cognition Disorders Psychology |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 22:385-391 |
| ISSN: | 1421-9824 1420-8008 |
| Popis: | We assessed the diagnostic accuracy of the German version of the Addenbrooke’s Cognitive Examination (ACE) in identifying early Alzheimer’s disease (AD) and mild vascular dementia (VaD) in comparison with the conventional Mini-Mental State Examination (MMSE). The study refers to 50 patients with mild dementia of AD, 26 patients with mild dementia of vascular etiology and to 54 cognitively normal subjects. The ACE and MMSE were validated against an expert diagnosis based on a comprehensive diagnostic workup. Statistical analysis was performed using the receiver operator characteristics method. The optimal cut-off score for the ACE for detecting dementia in patients with early AD was 85/86, which had a sensitivity of 93% and a specificity of 86%. The optimal cut-off for the ACE for the identification of dementia in patients with mild VaD was also 85/86 and it had a sensitivity of 93% and a specificity of 100%. The ĸ values imply a substantial agreement between the diagnoses made by the ACE and the MMSE. The German version of the ACE is a short and practical but accurate test battery for the identification of AD and VaD, assessing a broad range of cognitive functions and providing a wide profile of cognitive functions/dysfunctions. |
| Databáze: | OpenAIRE |
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