Screening hemostatic defects in Saudi University students with unexplained menorrhagia: a diagnosis, which could be missed
| Autor: | Salwa Bakr, Tarek Owaidah, Mustafa Owaidah, Anwar Abdullah Almughiyri, Ameera Abdullah Almutairi, Ahmad Dawalibi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Universities Cross-sectional study Anemia Platelet dysfunction Saudi Arabia 030204 cardiovascular system & hematology 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors Von Willebrand disease Medicine Humans Students Menorrhagia Hemostasis Menstrual blood loss medicine.diagnostic_test business.industry Obstetrics Complete blood count Hematology General Medicine medicine.disease female genital diseases and pregnancy complications Blood Cell Count Cross-Sectional Studies Coagulation Female Bleeding tendencies business 030215 immunology |
| Zdroj: | Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 32(4) |
| ISSN: | 1473-5733 |
| Popis: | Bleeding disorders are a common cause of unexplained menorrhagia in adolescents. However, there is lack of information provided on Arab girls. To estimate the prevalence of coagulation factor deficiencies and platelet dysfunction among Saudi university students with unexplained menorrhagia. In this cross sectional study, 463 adolescent girls surveyed for having heavy menses for further evaluation of underlying bleeding tendencies using screening standardized questionnaire. Only 109 girls out of the total 463 girls reported menorrhagia and were included in the evaluation. All girls with menorrhagia were evaluated by Pictorial blood assessment chart (PBAC) for precise evaluation of menstrual blood loss (PBAC score >100), had underwent pelvic ultrasonography and screening of hemostatic abnormalities (complete blood count, PFA-100, PT, aPTT, vWF:RCo, vWF:Ag, coagulation factors assay). On the basis of the score of PBAC more than 100, 25.6% (28/109) of adolescent women (age ranged: 17-25 years old) had confirmed menorrhagia. In 30.8% of them, an ultimate diagnosis of bleeding tendency or hemostatic abnormality was detected [five cases of probable von Willebrand disease (vWD) or low level of vWF:Ag and/or vWF:RCo, two cases of probable platelet dysfunction, and one case of factorV (FV) deficiency]. Anemia was found in 39.28% (11/28) of them; however, only 4 (36%) had received iron supplements. Our study demonstrated that hemostatic defects are not uncommon in Saudi adolescent women presenting with menorrhagia but mostly unrecognized and untreated. It is probably advisable to screen women with menorrhagia for these defects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|