l-Arginine infusion after ischaemia-reperfusion of rat kidney enhances lipid peroxidation
| Autor: | Christoph Thiemermann, Jean-Paul Cristol, AndréCrastes de Paulet, Marie-Christine Guerin, Jean Torreilles |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Arginine Immunology Ischemia Pharmacology Kidney Nitric Oxide Renal Circulation Nitric oxide Lipid peroxidation chemistry.chemical_compound Superoxides Cricetinae medicine Animals Rats Wistar Aldehydes Superoxide medicine.disease Rats medicine.anatomical_structure Biochemistry chemistry Reperfusion Injury Renal blood flow Vascular resistance Vascular Resistance Lipid Peroxidation Reactive Oxygen Species |
| Zdroj: | Journal of Lipid Mediators and Cell Signalling. 13:9-17 |
| ISSN: | 0929-7855 |
| DOI: | 10.1016/0929-7855(95)00010-0 |
| Popis: | To assess the role of superoxide (O2−) and nitric oxide (NO) in ischaemic-reperfusion-induced acute renal failure, we investigated whether an activation of the L-arginine-NO pathway contributes to ischaemia-reperfusion-induced kidney membrane peroxidation by measurement of 4-hydroxynonenal (HNE) content in anaesthetized rats submitted to acute renal ischaemia. Following ischaemia-reperfusion injury, renal blood flow (RBF) was significantly reduced, while renal vascular resistance was significantly increased. Infusion of neither L -arginine nor D -arginine led to a recovery of RBF. L -Arginine, but not D -arginine, caused a significant increase in HNE accumulation in the ischaemic kidney. L -Arginine infusion enhanced the degree of lipid peroxidation afforded by ischaemia-reperfusion injury in the kidney suggesting that products of the endogenous L -arginine-NO pathway may react with O2− to initiate lipid peroxidation. |
| Databáze: | OpenAIRE |
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