Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike times in the neocortex
| Autor: | Hyowon Chung, Michael M. Kohl, Blake A. Richards, Hyun Jae Jang, James M. Rowland, Jeehyun Kwag |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Interneuron
genetic structures Neurophysiology Sensory system Gating Optogenetics Inhibitory postsynaptic potential 03 medical and health sciences 0302 clinical medicine medicine Research Articles 030304 developmental biology 0303 health sciences Multidisciplinary Neocortex biology musculoskeletal neural and ocular physiology fungi SciAdv r-articles Barrel cortex medicine.anatomical_structure nervous system biology.protein Neuroscience 030217 neurology & neurosurgery Parvalbumin Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | Sensory information–driven spikes are synchronized across cortical layers by distinct subtypes of interneurons. Synchronization of precise spike times across multiple neurons carries information about sensory stimuli. Inhibitory interneurons are suggested to promote this synchronization, but it is unclear whether distinct interneuron subtypes provide different contributions. To test this, we examined single-unit recordings from barrel cortex in vivo and used optogenetics to determine the contribution of parvalbumin (PV)– and somatostatin (SST)–positive interneurons to the synchronization of spike times across cortical layers. We found that PV interneurons preferentially promote the synchronization of spike times when instantaneous firing rates are low (12 Hz). Furthermore, using a computational model, we demonstrate that these effects can be explained by PV and SST interneurons having preferential contributions to feedforward and feedback inhibition, respectively. Our findings demonstrate that distinct subtypes of inhibitory interneurons have frequency-selective roles in the spatiotemporal synchronization of precise spike times. |
| Databáze: | OpenAIRE |
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