A modeling study of functional magnetic resonance imaging to individualize target definition of seminal vesicles for external beam radiotherapy
| Autor: | Marianne C. Aznar, J.P. Bangsgaard, Ivan R. Vogelius, Peter Meidahl Petersen, J.B. Thomsen, Sidsel Marie Skov Damkjær, Svetlana I. Petersen |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Organs at Risk
Male Seminal Vesicles/pathology medicine.medical_treatment Prostatic Neoplasms/pathology Models Biological Article 030218 nuclear medicine & medical imaging Magnetic Resonance Imaging/methods 03 medical and health sciences Prostate cancer 0302 clinical medicine Nuclear magnetic resonance medicine Humans Radiology Nuclear Medicine and imaging External beam radiotherapy Organs at Risk/radiation effects Radiotherapy Planning Computer-Assisted/methods medicine.diagnostic_test Manchester Cancer Research Centre business.industry Vesicle ResearchInstitutes_Networks_Beacons/mcrc Radiotherapy Planning Computer-Assisted food and beverages Prostatic Neoplasms Seminal Vesicles Magnetic resonance imaging Dose-Response Relationship Radiation Radiotherapy Dosage Hematology General Medicine Original Articles Radiotherapy Intensity-Modulated/methods medicine.disease Magnetic Resonance Imaging Oncology 030220 oncology & carcinogenesis Radiotherapy Intensity-Modulated Functional magnetic resonance imaging business Nuclear medicine |
| Zdroj: | Damkjær, S, Thomsen, J B, Petersen, S I, Bangsgaard, J P, M Petersen, P, Vogelius, I R & Aznar, M C 2017, ' A modeling study of functional magnetic resonance imaging to individualize target definition of seminal vesicles for external beam radiotherapy ', Acta Oncologica, vol. 56, no. 6, pp. 799-805 . https://doi.org/10.1080/0284186X.2017.1300684 Acta Oncologica (Stockholm, Sweden) Damkjaer, S, Thomsen, J B, Petersen, S I, Bangsgaard, J P, Petersen, P M, Vogelius, I R & Aznar, M C 2017, ' A modeling study of functional magnetic resonance imaging to individualize target definition of seminal vesicles for external beam radiotherapy ', Acta Oncologica, vol. 56, no. 6, pp. 799-805 . https://doi.org/10.1080/0284186X.2017.1300684 |
| DOI: | 10.1080/0284186X.2017.1300684 |
| Popis: | Background Pre-treatment magnetic resonance imaging (MRI) can give patient-specific evaluation of 25 suspected pathologically-involved volumes in the seminal vesicles (SV) in prostate cancer patients. By 26 targeting this suspicious volume we hypothesize that radiotherapy is more efficient without introducing more 27 toxicity. In this study we evaluate the concept of using MRI-defined target volumes in terms of tumor 28 control probability (TCP) and rectal normal tissue complication probability (NTCP). Materials and methods Twenty-one high-risk prostate cancer patients were included. Pre-treatment CT 30 images, T2 weighted (T2w) MRI and two multi-parametric MRI were acquired. Overlap between a 31 suspicious volume in the SV observed on T2w images and a suspicious volume observed on either multi-32 parametric MRI was assumed to reflect a true malignant region (named “MRI positive”). In addition the 33 entire SV on the CT-scan was delineated. Three treatment plans of 2Gyx39 fractions were generated per 34 patient: one covering the MRI positive volume in SV and prostate with margin of 11 mm to the MRI positive 35 in the SV and two plans covering prostate and SV using 11mm and 7mm SV margin, respectively. All plans 36 prescribed the same PTV mean dose. Rectal NTCP grade≥2 was evaluated with the Lyman-Kutcher-Burman 37 model and TCP was estimated by a logistic model using the combined MRI positive volume in SV and 38 prostate as region-of-interest. Results 14/21 patients were classified as MRI positive, 6 of which had suspicious volumes in all three MRI 40 modalities. On average TCP for the plan covering prostate and the MRI positive volume was 3% higher (up 41 to 11%) than the two other plans which was statistically significant. The increased TCP was obtained without 42 increasing rectal NTCP grade≥2. Conclusion Using functional MRI for individualized target delineation in the seminal vesicles may improve 44 the treatment outcome in radiotherapy of prostate cancer without increasing the rectal toxicity. |
| Databáze: | OpenAIRE |
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