Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories
| Autor: | Kechun Yang, Xiaowen Zhang, Theodoros Tsetsenis, Julianne A. Wilson, Elizabeth N. Krizman, Julia Kathleen Badyna, Steven A. Thomas, John A. Dani, Manivannan Subramaniyan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Dopamine Hippocampus Substantia nigra Biology Midbrain Mice Memory Mesencephalon medicine Animals Learning Fear conditioning Multidisciplinary Pars compacta Dopaminergic Neurons Ventral Tegmental Area Dopaminergic Fear Biological Sciences Mice Inbred C57BL Optogenetics Substantia Nigra Ventral tegmental area medicine.anatomical_structure nervous system Female Neuroscience medicine.drug |
| Zdroj: | Proc Natl Acad Sci U S A |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.2111069118 |
| Popis: | Aversive memories are important for survival, and dopaminergic signaling in the hippocampus has been implicated in aversive learning. However, the source and mode of action of hippocampal dopamine remain controversial. Here, we utilize anterograde and retrograde viral tracing methods to label midbrain dopaminergic projections to the dorsal hippocampus. We identify a population of midbrain dopaminergic neurons near the border of the substantia nigra pars compacta and the lateral ventral tegmental area that sends direct projections to the dorsal hippocampus. Using optogenetic manipulations and mutant mice to control dopamine transmission in the hippocampus, we show that midbrain dopamine potently modulates aversive memory formation during encoding of contextual fear. Moreover, we demonstrate that dopaminergic transmission in the dorsal CA1 is required for the acquisition of contextual fear memories, and that this acquisition is sustained in the absence of catecholamine release from noradrenergic terminals. Our findings identify a cluster of midbrain dopamine neurons that innervate the hippocampus and show that the midbrain dopamine neuromodulation in the dorsal hippocampus is sufficient to maintain aversive memory formation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|