Mortality and treatment failure among HIV-infected adults in Dar Es Salaam, Tanzania
| Autor: | James Okuma, Wafaie W. Fawzi, Akum Aveika, Sylvia Kaaya, Deo Mtasiwa, Guerino Chalamilla, Donna Spiegelman, Happiness Koda, Beatrice Christian, Claudia Hawkins |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Anti-HIV Agents Immunology Population HIV Infections Dermatology Tanzania Hemoglobins Sex Factors Acquired immunodeficiency syndrome (AIDS) Interquartile range Risk Factors Case fatality rate medicine Humans Prospective Studies Treatment Failure education Prospective cohort study Developing Countries education.field_of_study biology business.industry Mortality rate Stavudine Middle Aged medicine.disease biology.organism_classification CD4 Lymphocyte Count Infectious Diseases Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002). 11(5) |
| ISSN: | 1545-1097 |
| Popis: | Objectives: Monitoring antiretroviral treatment (ART) outcomes is essential for assessing the success of HIV care and treatment programs in resource-limited settings (RLS). Methods: Longitudinal analyses of clinical and immunologic parameters in HIV-infected adults initiated on ART between November 2004 and June 2008 at Management and Development for Health (MDH)-Presidents Emergency Plan For AIDS Relief PEPFAR supported HIV care and treatment clinics in Tanzania. Results: A total of 12 842 patients were analyzed (65.9% female, median baseline CD4 count, 106 cells/mm3). Significant improvements in immunologic status were observed with an increase in CD4 count to 298 (interquartile range [IQR] 199-416), 372 (256-490) and 427 (314-580) cells/mm3, at 1, 2, and 3 years, respectively. Overall mortality was 13.1% (1682 of 12 842). Male sex, World Health Organization (WHO) stage III/IV, CD4 3, hemoglobin (Hgb) Conclusions: Closer monitoring of males and patients with advanced HIV disease following ART initiation may improve clinical and immunologic outcomes in these individuals. |
| Databáze: | OpenAIRE |
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