Effect of oxytocin during labor on neonatal acidemia
| Autor: | Cristina Plevani, John C. Pezzullo, Maddalena Incerti, Alessandro Ghidini, Serena Mussi, Anna Locatelli |
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| Přispěvatelé: | Mussi, S, Incerti, M, Plevani, C, Ghidini, A, Pezzullo, J, Locatelli, A |
| Rok vydání: | 2015 |
| Předmět: |
Pediatrics
medicine.medical_specialty Time Factors Cardiotocography MED/40 - GINECOLOGIA E OSTETRICIA Logistic regression Oxytocin tachysystole 03 medical and health sciences 0302 clinical medicine Fetus Labor Stage Second Pregnancy Risk Factors Bayesian multivariate linear regression Active phase Oxytocics Medicine neonatal academia Humans 030212 general & internal medicine Labor Induced Prospective Studies 030219 obstetrics & reproductive medicine business.industry Obstetrics Infant Newborn Obstetrics and Gynecology Heart Rate Fetal Obstetric Labor Complications Fetal heart rate Logistic Models Fetal heart rate tracing Maximum dose Pediatrics Perinatology and Child Health Female business Acidosis medicine.drug |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 29(19) |
| ISSN: | 1476-4954 |
| Popis: | Objective: To assess the factors affecting neonatal acidemia, including occurrence of tachysystole/hypertonus in fetuses exposed to oxytocin during labour and with continuously-monitored fetal heart rate (FHR) tracings. Methods: Prospective observational study of all women with term pregnancies who received oxytocin for induction/augmentation of labour. FHR tracings were prospectively classified using ACOG classification. Independent predictors of neonatal acidemia were identified using multivariate linear regression with p < 0.05 considered significant. Results: We included 430 women, 236 of whom (54.9%) had spontaneous onset of labour. The duration of active phase of the second stage of labour and the presence of abnormal FHR tracing during labour were significantly associated with UA pH (p < 0.001) and BE (p < 0.001), while maximum dose of oxytocin (p < 0.17; p < 0.7) and tachysystole (p < 0.9; p < 0.8) were not. At logistic regression, the duration of active phase of the second stage of labour was independently predictive of neonatal acidemia (p < 0.009) while abnormal FHR tracing approached significance (p < 0.088). Conclusions: In women receiving oxytocin during labour, the duration of active phase of the second stage of labour correlates with neonatal acidemia, whereas maximum dose of oxytocin, duration of oxytocin administration and occurrence of tachysystole during labour do not. |
| Databáze: | OpenAIRE |
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