Abdominal subcutaneous fat thickness and homeostasis model assessment of insulin resistance as simple predictors of nonalcoholic steatohepatitis
| Autor: | Afaf Tawfik, Mona A. Hegazy, Ahmed A M Ezzat, Mervat E. Behiry, Mervat Naguib, Maysa A Samy |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
obesity medicine.medical_specialty medicine.diagnostic_test Receiver operating characteristic abdominal subcutaneous fat thickness business.industry hepatic steatosis nutritional and metabolic diseases medicine.disease Gastroenterology Obesity Insulin resistance insulin resistance Liver biopsy Diabetes mellitus Internal medicine Nonalcoholic fatty liver disease Internal Medicine medicine Steatosis business Body mass index Targets and Therapy [Diabetes Metabolic Syndrome and Obesity] Original Research |
| Zdroj: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| ISSN: | 1178-7007 |
| Popis: | Mona A Hegazy,1 Maysa A Samy,2 Afaf Tawfik,2 Mervat M Naguib,1 Ahmed Ezzat,1 Mervat E Behiry11Department of Internal Medicine, School of Medicine, Cairo University, Cairo, Egypt; 2National Nutrition Institute, Cairo, EgyptBackground: Obesity, insulin resistance, and diabetes are major risk factors for nonalcoholic fatty liver disease (NAFLD). This study aims to evaluate the association between different grades of NAFLD and abdominal subcutaneous fat thickness with the homeostasis model assessment of insulin resistance (HOMA-IR).Methods: In this pilot study, 59 obese nondiabetic participants with NAFLD were enrolled. Total cholesterol, HbA1c, and HOMA-IR were measured. Abdominal subcutaneous fat thickness in the midline just below the xiphoid process in front of the left lobe of the liver (LSFT) and in the umbilical region (USFT), and the degree of hepatic steatosis, were evaluated by ultrasound scans, and their correlation with the degree of steatosis and the NAFLD Activity Score in liver biopsy was assessed.Results: Of the 59 studied participants, 15 had mild, 17 had moderate, and 27 had severe hepatic steatosis by abdominal ultrasound. Themean ± SD HOMA-IR level in NAFLD patients was 5.41±2.70. The severity of hepatic steatosis positively correlated with body mass index (P |
| Databáze: | OpenAIRE |
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