Controlled delivery of paclitaxel from stent coatings using novel styrene maleic anhydride copolymer formulations
| Autor: | Mark Boden, Nikolai Teigen, Marlene Schwarz, Ken Chan, Robert E. Richard |
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| Rok vydání: | 2009 |
| Předmět: |
Materials science
Paclitaxel Biocompatibility Polymers Swine Biomedical Engineering Microscopy Atomic Force Elastomer Biomaterials chemistry.chemical_compound Drug Delivery Systems Differential scanning calorimetry Coated Materials Biocompatible Copolymer Animals Composite material Styrene Maleic Anhydrides Drug Carriers Calorimetry Differential Scanning Metals and Alloys Maleic anhydride Antineoplastic Agents Phytogenic Controlled release chemistry Styrene maleic anhydride Microscopy Electron Scanning Ceramics and Composites Stents Polymer blend Chromatography Liquid |
| Zdroj: | Journal of Biomedical Materials Research Part A. :522-532 |
| ISSN: | 1552-4965 1549-3296 |
| Popis: | The controlled release of paclitaxel (PTx) from stent coatings comprising an elastomeric polymer blended with a styrene maleic anhydride (SMA) copolymer is described. The coated stents were characterized for morphology by scanning electron microscopy (SEM) and atomic force microscopy (AFM), and for drug release using high-performance liquid chromatography (HPLC). Differential scanning calorimetry (DSC) was used to measure the extent of interaction between the PTx and polymers in the formulation. Coronary stents were coated with blends of poly(b-styrene-b-isobutylene-b-styrene) (SIBS) and SMA containing 7% or 14% maleic anhydride (MA) by weight. SEM examination of the stents showed that the coating did not crack or delaminate either before or after stent expansion. Examination of the coating surface via AFM after elution of the drug indicated that PTx resides primarily in the SMA phase and provided information about the mechanism of PTx release. The addition of SMA altered the release profile of PTx from the base elastomer coatings. In addition, the presence of the SMA enabled tunable release of PTx from the elastomeric stent coatings, while preserving mechanical properties. Thermal analysis reveled no shift in the glass transition temperatures for any of the polymers at all drug loadings studied, indicating that the PTx is not miscible with any component of the polymer blend. An in vivo evaluation indicated that biocompatibility and vascular response results for SMA/SIBS-coated stents (without PTx) are similar to results for SIBS-only-coated and bare stainless steel control stents when implanted in the non-injured coronary arteries of common swine for 30 and 90 days. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009 |
| Databáze: | OpenAIRE |
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