Antibacterial activity of flavans from crinum distichum
| Autor: | Frederick Annang, Ingrid Simo Konga, Romeol Romain Koagne, Gabin Thierry M. Bitchagno, Ignacio Pérez-Victoria, Mercedes de la Cruz, Francisca Vicente, Pierre Tane, Fernando Reyes |
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| Předmět: |
Pharmacology
food.ingredient Traditional medicine biology 010405 organic chemistry Chemistry Crinum distichum Plant Science General Medicine Amaryllidaceae biology.organism_classification 01 natural sciences High-performance liquid chromatography 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound food Complementary and alternative medicine Phytochemical Flavan Herb Drug Discovery Antibacterial activity |
| Zdroj: | Scopus-Elsevier CIÊNCIAVITAE |
| Popis: | The phytochemical study of the ethanol extract from Crinum distichum Herb. was carried out using reversed phase high performance liquid chromatography and afforded a new natural flavan (1), along with (2 S)-4'-hydroxy-7-methoxyflavan (2), (2 R)-4'-hydroxy-5,7-dimethoxyflavan (3), hippadine (4) and hippacine(5). The structure of the new compound was elucidated using a combination of NMR and HRESI-MS analysis while the structures of the known compounds were established by comparison of their spectroscopic data with those of similar reported compounds. Compounds 2–5 also had moderate activity (32> MIC> 16 μg/mL) against methicillin resistant (MRSA) and methicillin sensitive (MSSA) Staphylococcus aureus (both Gram-positive bacteria), whilst compound 1 was inactive against these two bacterial strains (MIC>128μg/mL). None of the compounds was active against the Gram-negative bacterial strains Escherichia coli and Klesbesiella pneumoniae. The research described herein confirms once more that, plants of the Crinum genus continue to be a rich and underexploited source of new small molecules that could lead to the discovery of new bioactive compounds. |
| Databáze: | OpenAIRE |
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