Inflammatory breast cancer in North Africa: Comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco
| Autor: | Amr S. Soliman, Elizabeth D. Kantor, Mohab Eissa, Celina G. Kleer, Karima Mrad, E.J. McSpadden, Kathy A. Toy, Hussein M. Khaled, Sofia D. Merajver, Quin Xiao, Saad Eissa, Sherif Omar, Claire Hampton, Abdel Latif Benider, An Chi Lo, Mehdi Karkouri, Farhat Ben Ayed |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Oncology
Adult rho GTP-Binding Proteins Cancer Research medicine.medical_specialty Pathology Tunisia RhoC North africa Inflammatory breast cancer Article Metastasis Breast cancer Internal medicine Medicine Humans skin and connective tissue diseases Aged Molecular Epidemiology biology Molecular epidemiology business.industry Age Factors General Medicine Middle Aged medicine.disease Neoplastic Cells Circulating Morocco rhoC GTP-Binding Protein biology.protein Etiology Egypt Female Inflammatory Breast Neoplasms business RhoC GTP-Binding Protein |
| Popis: | Understanding molecular characteristics that distinguish inflammatory breast cancer (IBC) from non-IBC is crucial for elucidating breast cancer etiology and management. We included 3 sets of patients from Egypt (48 IBC and 64 non-IBC), Tunisia (24 IBC and 40 non-IBC), and Morocco (42 IBC and 41 non-IBC). Egyptian IBC patients had the highest combined erythema, edema, peau d'orange, and metastasis among the 3 IBC groups. Egyptian IBC tumors had the highest RhoC expression than Tunisians and Moroccan IBCs (87% vs. 50%, vs. 38.1, for the 3 countries, respectively). Tumor emboli were more frequent in Egyptian IBC than non-IBC (Mean ±SD: 14.1 ± 14.0 vs. 7.0 ± 12.9, respectively) ( P< 0.001) and Tunisians (Mean ± SD: 3.4 ± 2.5 vs. 1.9 ± 2.0, respectively) ( P< 0.01). There was no difference of emboli in Moroccan tumors (1.7 ± 1.2 vs. 1.8 ± 1.2 for IBC and non-IBC, respectively (P = 0.66). This study illustrates that RhoC overexpression and tumor emboli are more frequent in IBC relative to non-IBC from Egypt and Tunisia. Tumors of Moroccans were significantly different from Egyptian and Tunisian tumors for RhoC expression and emboli. Future studies should focus on relating epidemiologic factors and clinical pictures to molecular features of IBC in these and other populations. |
| Databáze: | OpenAIRE |
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