Cardiac allograft vasculopathy following fecal microbiota transplantation for recurrent C. difficile infection
| Autor: | Kyle Jensen, Ashwin K. Lal, Elizabeth D. Knackstedt, Spencer B. Barfuss, Kimberly M. Molina |
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| Rok vydání: | 2018 |
| Předmět: |
Graft Rejection
Male Reoperation medicine.medical_specialty medicine.drug_class Antibiotics 030230 surgery Cardiac allograft vasculopathy Gastroenterology 03 medical and health sciences 0302 clinical medicine Recurrence Internal medicine medicine Humans Vascular Diseases Pneumatosis intestinalis Transplantation biology Clostridioides difficile business.industry Myocardium Organ dysfunction Fecal bacteriotherapy Fecal Microbiota Transplantation Clostridium difficile Allografts Coronary Vessels Anti-Bacterial Agents Diarrhea Infectious Diseases Child Preschool Clostridium Infections biology.protein Heart Transplantation 030211 gastroenterology & hepatology medicine.symptom Antibody business |
| Zdroj: | Transplant Infectious Disease. 20:e12983 |
| ISSN: | 1398-2273 |
| Popis: | We report the case of a 3-year-old male who developed recurrent Clostridium difficile infection after receiving an orthotopic heart transplant. Despite multiple courses of antibiotics, C. difficile infection was persistent and he underwent a fecal microbiota transplant. The patient responded with resolution of his diarrhea. However, within 2 months he developed severe mixed rejection with high circulating donor-specific antibodies and significant coronary vasculopathy. Organ dysfunction led to the need for re-transplantation. The patient's postoperative course has since been complicated by pneumatosis intestinalis and recurrent C. difficile infection. |
| Databáze: | OpenAIRE |
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