Balancing Vancomycin Efficacy and Nephrotoxicity: Should We Be Aiming for Trough or AUC/MIC?
| Autor: | Holly D. Maples, Ashley S. Crumby, Karisma Patel |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Methicillin-Resistant Staphylococcus aureus medicine.medical_specialty Microbial Sensitivity Tests Nephrotoxicity Minimum inhibitory concentration Pharmacotherapy Pharmacokinetics Vancomycin Internal medicine medicine Humans Pharmacology (medical) Dosing Child Intensive care medicine business.industry Area under the curve Staphylococcal Infections Anti-Bacterial Agents Area Under Curve Pharmacodynamics Pediatrics Perinatology and Child Health business medicine.drug |
| Zdroj: | Pediatric Drugs. 17:97-103 |
| ISSN: | 1179-2019 1174-5878 |
| Popis: | Sixty years later, the question that still remains is how to appropriately utilize vancomycin in the pediatric population. The Infectious Diseases Society of America published guidelines in 2011 that provide guidance for dosing and monitoring of vancomycin in adults and pediatrics. However, goal vancomycin trough concentrations of 15-20 μg/mL for invasive infections caused by methicillin-resistant Staphylococcus aureus were based primarily on adult pharmacokinetic and pharmacodynamic data that achieved an area under the curve to minimum inhibitory concentration ratio (AUC/MIC) of ≥400. Recent pediatric literature shows that vancomycin trough concentrations needed to achieve the target AUC/MIC are different than the adult goal troughs cited in the guidelines. This paper addresses several thoughts, including the role of vancomycin AUC/MIC in dosing strategies and safety monitoring, consistency in laboratory reporting, and future directions for calculating AUC/MIC in pediatrics. |
| Databáze: | OpenAIRE |
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