Increased substance P in subacromial bursa and shoulder pain in rotator cuff diseases
Autor: | Hideyuki Yamakawa, Kazutoshi Hamada, Masafumi Gotoh, Hiroaki Fukuda, Akio Inoue |
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Rok vydání: | 1998 |
Předmět: |
Adult
medicine.medical_specialty Visual analogue scale Subacromial bursitis Pain Substance P Antibodies Rotator Cuff Injuries Rotator Cuff chemistry.chemical_compound Bursitis medicine Humans Orthopedics and Sports Medicine Rotator cuff Aged Pain Measurement Shoulder Joint business.industry Rotator cuff injury Chronic pain Bursa Synovial Middle Aged medicine.disease Surgery medicine.anatomical_structure chemistry Cuff Subacromial bursa business |
Zdroj: | Journal of Orthopaedic Research. 16:618-621 |
ISSN: | 1554-527X 0736-0266 |
DOI: | 10.1002/jor.1100160515 |
Popis: | The subacromial bursa is recognized as a site associated with the shoulder pain caused by rotator cuff disease in the middle-aged and elderly. Substance P is contained in primary afferent nerves, and its quantity increases during chronic pain. The amount of substance P in the subacromial bursa of patients with rotator cuff disease was examined. Radioimmunoassay and immunohistochemistry were employed to quantify and localize substance P. The preoperative pain level was measured with a visual analogue scale with 0 as no pain, 5 as moderate, and 10 as severe. Thirty-seven patients that had undergone operation were divided into two groups: one composed of 19 patients with subacromial bursitis and a partial-thickness tear of the rotator cuff (nonperforated cuff) and the other composed of 18 patients with a full-thickness tear (perforated cuff). Subacromial bursae obtained from seven fresh cadavers with no shoulder pain before death were used as controls. The visual analogue scale showed significantly greater pain in the group with the nonperforated rotator cuff than in the group with the perforated cuff. Consistent with these results, the amount of substance P in the subacromial bursa was significantly greater in the former group than in the latter. Nerve fibers immunoreactive to substance P were localized around the vessels, with a larger number of fibers in the group with the nonperforated rotator cuff. Therefore, an increased amount of substance P in the subacromial bursa appears to correlate with the pain caused by rotator cuff disease. |
Databáze: | OpenAIRE |
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