Selective Arterial Embolization for the Treatment of Sacral and Pelvic Giant Cell Tumor: A Systematic Review
Autor: | Shaohui He, Yujie Liu, Haifeng Wei, Jianru Xiao, Wei Xu, Liu Weibo, Zhengwang Sun |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male Sacrum medicine.medical_specialty Adolescent Radiography MEDLINE Bone Neoplasms 030218 nuclear medicine & medical imaging Young Adult 03 medical and health sciences 0302 clinical medicine parasitic diseases medicine Humans Orthopedics and Sports Medicine Pelvic Bones Review Articles Pelvis Aged Pelvic Neoplasms Giant Cell Tumor of Bone Response rate (survey) Spinal Neoplasms business.industry Arterial Embolization Middle Aged Embolization Therapeutic Surgery Treatment Outcome Sexual dysfunction medicine.anatomical_structure Giant cell 030220 oncology & carcinogenesis Inclusion and exclusion criteria Female Radiology medicine.symptom business |
Zdroj: | Orthopaedic Surgery. 9:139-144 |
ISSN: | 1757-7853 |
Popis: | Giant cell tumor of the bone (GCTB) is a locally aggressive tumor with a certain distant metastatic rate. For sacral GCT (SGCT) and pelvic GCT (PGCT), surgery has its limitations, especially for unresectable or recurrent tumors. Selective arterial embolization (SAE) is reported to be an option for treatment in several cases, but there are few systematic reviews on the effects of SAE on SGCT and/or PGCT. Medline and Embase databases were searched for eligible English articles. Inclusion and exclusion criteria were conducted before searching. All the clinical factors were measured by SPSS software, with P‐values ≤0.05 considered statistically significant. A total of 9 articles were retrieved, including 44 patients receiving SAE ranging from 1 to 10 times. During the mean follow‐up period of 85.8 months, the radiographic response rate was 81.8%, with a local control and overall survival rate of 75% and 81.8%, respectively. No bowel, bladder, or sexual dysfunction was observed. Three patients developed distant metastases and finally died. Patients with primary tumors tended to have better prognosis than those with recurrence (P = 0.039). The favorable outcomes of SAE suggest that it may be an alternative treatment for SGCT and PGCT patients for whom surgery is not appropriate. |
Databáze: | OpenAIRE |
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