Benign Biliary Stricture after Yttrium-90 Radioembolization for Hepatocellular Carcinoma
| Autor: | Jin Wook Chung, Myungsu Lee, Ijin Joo, Hyo Cheol Kim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Carcinoma Hepatocellular Laboratory abnormality Radiation Dosage 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Humans Radiology Nuclear Medicine and imaging In patient Yttrium Radioisotopes Aged Retrospective Studies Biliary drainage Cholestasis business.industry Incidence (epidemiology) Liver Neoplasms Retrospective cohort study Middle Aged medicine.disease Embolization Therapeutic medicine.anatomical_structure Biliary ducts Treatment Outcome 030220 oncology & carcinogenesis Hepatocellular carcinoma Female Radiology Radiopharmaceuticals Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Journal of vascular and interventional radiology : JVIR. 31(12) |
| ISSN: | 1535-7732 |
| Popis: | Purpose To determine the frequency and possible causative factors of benign biliary stricture after radioembolization in patients with hepatocellular carcinoma (HCC). Materials and Methods This retrospective study comprised 232 patients with HCC who underwent yttrium-90 radioembolization between October 2015 and September 2019. Benign biliary stricture was defined as biliary ductal dilatation of segmental or lobar biliary ducts on follow-up images. Clinical and radiologic characteristics were compared using χ2 test or independent t test. Results Mean target perfused tissue dose was 224.6 Gy ± 106.8 (median, 205.7 Gy; range, 47.0–694.7 Gy). Of 232 patients, 15 (6.5%) had benign biliary stricture, which was detected from 3 weeks to 10.3 months (mean, 3.9 months; median, 3.2 months). Whereas 5 patients did not have any symptoms or signs associated with benign biliary stricture, 10 patients had cholangitis and/or laboratory abnormality requiring biliary drainage procedures and intravenous antibiotic therapy. Selective radioembolization through a caudate artery was performed in 55 (23.7%) patients. The incidence of benign biliary stricture was 16.4% (9/55) and 3.4% (6/177) in patients with and without selective radioembolization through a caudate artery, respectively (P = .002). Conclusions Benign biliary stricture following yttrium-90 radioembolization may be common among patients receiving selective treatment via a caudate artery. |
| Databáze: | OpenAIRE |
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