A divergent canine parvovirus type 2c (CPV-2c) isolate circulating in China
Autor: | Chuanfeng Li, Guangqing Liu, Guangbin Niu, Zongyan Chen, Jingyu Tang |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Microbiology (medical) China Mutation rate Parvovirus Canine animal diseases viruses 030106 microbiology Microbiology Parvoviridae Infections 03 medical and health sciences Negative selection Monophyly Dogs Genetics Animals Dog Diseases Molecular Biology Ecology Evolution Behavior and Systematics Whole genome sequencing biology Phylogenetic tree Strain (biology) Point mutation Canine parvovirus biology.organism_classification 030104 developmental biology Infectious Diseases |
Zdroj: | Infection, Genetics and Evolution. 73:242-247 |
ISSN: | 1567-1348 |
Popis: | The variability and the intrinsically high mutation rate of canine parvovirus type 2(CPV-2) increased the diversity of CPV-2 in canine populations. Since the first occurrence of CPV-2, three antigenic variants (2a, 2b and 2c) were detected and distributed worldwide. CPV-2c infection has been detected and increasingly reported in China. Here, a CPV-2c strain CPV-SH1516 was isolated and its complete genome sequence was first characterized. Compared with other CPV-2c isolates, CPV-2c isolates from China continued to evolve into divergent CPV-2c variants with specific unique amino acid substitutions under purifying selection. Emergence of CPV-2c isolates from China was driven by the unique gradual point mutations in key sites of VP2 rather than introduction from outside China. Combining sequence comparison with phylogenetic analysis based on the amino acid sequences of VP2, the vast majority of CPV-2c isolates from China formed a monophyletic cluster and CPV-SH1516 was a representative isolate of CPV-2c circulating in China. Overall, our study provides valuable insight into the evolutionary mechanism of CPV-2c. |
Databáze: | OpenAIRE |
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