Neuropsychological disorders in noncentral nervous system cancer: a review of objective cognitive impairment, depression and related rehabilitation options
| Autor: | Carlo Caltagirone, Giovanni Morone, Stefano Paolucci, Fulvia Di Iulio, Luca Cravello, Jacob Shofany |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
Antineoplastic Agents Dermatology 03 medical and health sciences 0302 clinical medicine Breast cancer Neoplasms medicine Humans Cognitive Dysfunction 030212 general & internal medicine Neuropsychological assessment Depression (differential diagnoses) Depressive Disorder Rehabilitation medicine.diagnostic_test business.industry Neuropsychology Cancer Cognition General Medicine medicine.disease Psychiatry and Mental health Hormonal therapy Neurology (clinical) business 030217 neurology & neurosurgery Clinical psychology |
| Popis: | The objective of the present review was to systematically characterize the types of cognitive impairment that are found in different non-brain types of cancer as measured by objective and validated tests, and also to further examine depression and cognitive function in cancer patients and explore their available rehabilitation treatments. A total of 29 articles were reviewed. Most of these studies suggest that chemotherapy as well as the combination of chemotherapy and hormonal therapy can influence cognition in different types of cancer patients. Breast cancer patients appear to be the most affected in neuropsychological function, specifically in terms of cognitive impairment and reduced quality of life, as compared to other non-brain solid tumours. Overall, the most impaired functions were verbal ability, memory, executive function, and motor speed. Chemotherapy-related cognitive dysfunction remains under-recognized and undertreated. The various studies reported differing and non-homogenous findings with mixed results, obtained by self-reporting and web-assisted assessment, with other confounding factors such as age and depression during both cancer diagnosis and treatment. An objective neuropsychological assessment is fundamental to avoid underestimation of the extent of chemobrain. Self-reported and web-assisted assessment may ultimately result in confusion between the neuropsychological signs of chemobrain versus those of depression. |
| Databáze: | OpenAIRE |
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