Dysregulation of the hypothalamo-pituitary-adrenal axis and duration of diabetes
| Autor: | Browny Collier, Alec Roy, Monique S. Roy |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism Eye disease Hypothalamo pituitary adrenal axis Pituitary-Adrenal System Adrenocorticotropic hormone Dexamethasone chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Internal medicine Diabetes mellitus Internal Medicine Humans Medicine Diabetic Retinopathy business.industry Retinal Plasma levels medicine.disease Diabetes Mellitus Type 1 chemistry Female business Complication Retinopathy |
| Zdroj: | Journal of Diabetic Complications. 5:218-220 |
| ISSN: | 0891-6632 |
| DOI: | 10.1016/0891-6632(91)90079-5 |
| Popis: | We compared insulin-dependent diabetic outpatients with and without retinopathy for plasma indices of hypothalamo-pituitary-adrenal (HPA) axis activity. Diabetic patients with moderate-to-severe retinopathy had significantly higher postdexamethasone plasma levels of adrenocorticotropic hormone than patients with minimal or no retinopathy. However, when duration of diabetes was taken into account this difference was no longer significant. These data suggest that dysregulation of the HPA axis and retinal microvascular complications found in diabetic patients may both be a function of duration of diabetes. |
| Databáze: | OpenAIRE |
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