The Activity of Candidate Virucidal Agents, Low pH and Genital Secretions against HIV-1 In Vitro
| Autor: | D. J. Jeffries, T. J. O'Connor, D. Kinchington, H O Kangro |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Time Factors Octoxynol medicine.drug_class Nonoxynol Drug Evaluation Preclinical Semen Dermatology Pharmacology Spermatocidal Agents 03 medical and health sciences 0302 clinical medicine Antiseptic Cell Adhesion Humans Medicine Pharmacology (medical) 030212 general & internal medicine Infectivity 030505 public health business.industry Spermicide Chlorhexidine Public Health Environmental and Occupational Health Biological activity Hydrogen-Ion Concentration Virology Mucus In vitro Administration Intravaginal Infectious Diseases Anti-Infective Agents Local Cervix Mucus HIV-1 Female Benzalkonium Compounds 0305 other medical science business medicine.drug |
| Zdroj: | International Journal of STD & AIDS. 6:267-272 |
| ISSN: | 1758-1052 0956-4624 |
| DOI: | 10.1177/095646249500600409 |
| Popis: | Summary: The effect of low pH, normally present in the female genital tract, on HIV viability was examined. HIV is more acid stable than previously reported with no substantial reduction in infectivity occurring until pH levels are reduced below 4.5. The virucidal activity of 3 topical spermicides and chlorhexidine was assessed in vitro using previously established and newly modified assay systems. None of the agents tested had a selectivity index (SI) greater than 5.2. Semen and cervical secretions were assessed for their ability to inhibit HIV-1. While no virucidal effect was found in the latter, seminal fluid was found to have significant activity against HIV-1 and a SI of approximately 50. |
| Databáze: | OpenAIRE |
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