Corrigendum to: Transcriptome Assessment of Erythema Migrans Skin Lesions in Patients With Early Lyme Disease Reveals Predominant Interferon Signaling
| Autor: | Mary M. Petzke, Yanmei Wang, Carla Williams, Peter J. Munson, Cumhur Y Demirkale, Ira B. Schwartz, Jun Yang, Gary P. Wormser, Chyi-Chia Richard Lee, Adriana Marques, Ronald L. Hornung, Siu-Ping Turk |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Biopsy Transcriptome Lyme disease Interferon medicine Immunology and Allergy Humans In patient Aged Skin Lyme Disease business.industry Gene Expression Profiling Middle Aged medicine.disease Dermatology Corrigenda Infectious Diseases Host-Pathogen Interactions Erythema migrans Female Interferons Skin lesion business medicine.drug Signal Transduction |
| Zdroj: | J Infect Dis |
| Popis: | The most common clinical manifestation of early Lyme disease is the erythema migrans (EM) skin lesion that develops at the tick bite site typically between 7 and 14 days after infection with Borreliella burgdorferi. The host-pathogen interactions that occur in the skin may have a critical role in determining outcome of infection.Gene arrays were used to characterize the global transcriptional alterations in skin biopsy samples of EM lesions from untreated adult patients with Lyme disease in comparison to controls.The transcriptional pattern in EM biopsies consisted of 254 differentially regulated genes (180 induced and 74 repressed) characterized by the induction of chemokines, cytokines, Toll-like receptors, antimicrobial peptides, monocytoid cell activation markers, and numerous genes annotated as interferon (IFN)-inducible. The IFN-inducible genes included 3 transcripts involved in tryptophan catabolism (IDO1, KMO, KYNU) that play a pivotal role in immune evasion by certain other microbial pathogens by driving the differentiation of regulatory T cells.This is the first study to globally assess the human skin transcriptional response during early Lyme disease. Borreliella burgdorferi elicits a predominant IFN signature in the EM lesion, suggesting a potential mechanism for spirochetal dissemination via IDO1-mediated localized immunosuppression. |
| Databáze: | OpenAIRE |
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