Serum gamma-glutamyltransferase within its normal range predicts a chronic elevation of alanine aminotransferase: a four year follow-up study
| Autor: | Ji Sun Lim, David R. Jacobs, Jin Hun Yang, Myung Hwa Ha, Duk Hee Lee |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.disease_cause digestive system Biochemistry Gastroenterology Pathogenesis Reference Values Risk Factors Internal medicine Epidemiology medicine Humans Alanine aminotransferase Gamma-glutamyltransferase Normal range biology business.industry Alanine Transaminase General Medicine gamma-Glutamyltransferase Middle Aged Health Surveys digestive system diseases Oxidative Stress Relative risk Alcohols biology.protein business Body mass index Oxidative stress Follow-Up Studies |
| Zdroj: | Free radical research. 39(6) |
| ISSN: | 1071-5762 |
| Popis: | Previous epidemiological and experimental studies support the concept that serum gamma-glutamyltransferase (GGT) activity within its normal range is related to oxidative stress. Since oxidative stress plays a crucial role in the pathogenesis of various liver diseases, serum GGT may predict development of liver damage.A total of 6,523 healthy male workers with normal alanine aminotransferase (ALT,35 U/l) in a steel manufacturing company were followed for four years. Liver damage was defined as a chronic elevation of serum ALT (both 2001 and 2002).After adjusting for age, body mass index, alcohol consumption, cigarette smoking, exercise, and baseline value of ALT, in comparison with the group whose GGT level was10 U/l, the adjusted relative risks for elevated ALT level among those with GGT levels 10-19, 20-29, 30-39, and over 40 U/l was 1.0, 2.5, 4.7, 7.4, and 12.0, respectively (P for trend0.01). More importantly, this association was similarly observed even among non-drinkers; the corresponding relative risks were 1.0, 1.8, 3.8, 5.6, and 6.2 (P for trend0.01). However baseline ALT did not predict abnormal GGT level four years later.Serum GGT levels within normal range predict incidence of chronic elevation of ALT. Oxidative stress might explain this relationship. |
| Databáze: | OpenAIRE |
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