Hypothalamic-pituitary-adrenal axis and interleukin-6 activity in children with head trauma and syndrome of inappropriate secretion of antidiuretic hormone
| Autor: | Demetrios A. Koutras, Ioannis Ilias, Demetrios Gionis, George Mastorakos, Maria Moustaki, Emilia Mantzos, Ioannis Papadatos |
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| Rok vydání: | 2003 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Vasopressin Hypothalamo-Hypophyseal System Hydrocortisone Endocrinology Diabetes and Metabolism Pituitary-Adrenal System Urine Inappropriate ADH Syndrome Endocrinology Adrenocorticotropic Hormone Internal medicine Medicine Craniocerebral Trauma Humans Child Osmole business.industry Interleukin-6 Osmolar Concentration Infant medicine.disease Arginine Vasopressin medicine.anatomical_structure Blood Area Under Curve Child Preschool Pediatrics Perinatology and Child Health Syndrome of inappropriate antidiuretic hormone secretion Urine osmolality Secretagogue Female business hormones hormone substitutes and hormone antagonists Hypothalamic–pituitary–adrenal axis Antidiuretic Hormone |
| Zdroj: | Journal of pediatric endocrinologymetabolism : JPEM. 16(1) |
| ISSN: | 0334-018X |
| Popis: | Objective: Arginine vasopressin (AVP; antidiuretic hormone) and corticotropin-releasing hormone are the two major secretagogues of hypophyseal adrenocorticotropin (ACTH). Interleukin-6 (IL-6) is a potent stimulator of thehuman hypothalamic-pituitary-adrenal axis (HPA) and a secretagogue of both parvocellular and magnocelullar AVP. We have previously suggested that IL-6-stimulated AVP secretion may be the origin of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in inflammatory conditions. Study design: To further elucidate the relationship between IL-6 and SIADH as well as IL-6 and HPA axis activity, we studied eight previously healthy children (age 6.3 ′ 4.8 [mean ′ SD] years, weight 23.8 ′ 10.5 kg) who - after sustaining head trauma - presented SIADH during hospitalization (for 7.1 ′ 3.8 days) in the pediatric intensive care unit (P-ICU). Routine blood samples were taken twice daily at 08:00 and 20:00 hours. All children but one survived. Measurements included blood and urine osmolality (BlOsm and UrOsm, respectively), serum cortisol (F) and IL-6, plasma ACTH and AVP. Correlations were assessed with linear regression among the areas under the curve (AUC) of BlOsm, UrOsm, ACTH, F, IL-6 and AVP, separately for BlOsm values |
| Databáze: | OpenAIRE |
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