Introducing BisQ, A Bicoherence-Based Nonlinear Index to Explore the Heart Rhythm
| Autor: | Marlis Ontivero-Ortega, José Luis Hernández-Caceres, René Iván González-Fernández, Guido Nolte |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
0206 medical engineering 02 engineering and technology electrocardiogram recurrent quantification analysis Audiology arrhythmia lcsh:QA75.5-76.95 Correlation 03 medical and health sciences 0302 clinical medicine Medicine Heart rate variability Frequency coupling Bicoherence business.industry lcsh:T57-57.97 lcsh:Mathematics Applied Mathematics heart rate variability General Engineering lcsh:QA1-939 020601 biomedical engineering bispectrum Heart Rhythm Computational Mathematics Nonlinear system lcsh:Applied mathematics. Quantitative methods epilepsy Bispectral analysis lcsh:Electronic computers. Computer science business Bispectrum 030217 neurology & neurosurgery |
| Zdroj: | Mathematical and Computational Applications Volume 25 Issue 3 Mathematical and Computational Applications, Vol 25, Iss 45, p 45 (2020) |
| ISSN: | 2297-8747 |
| DOI: | 10.3390/mca25030045 |
| Popis: | Nonlinear frequency coupling is assessed with bispectral measures, such as bicoherence. In this study, BisQ, a new bicoherence-derived index, is proposed for assessing nonlinear processes in cardiac regulation. To find BisQ, 110 ten-minute ECG traces obtained from 55 participants were initially studied. Via bispectral analysis, a bicoherence matrix (BC) was obtained from each trace (0.06 to 1.8 Hz with a resolution of 0.01 Hz). Each frequency pair in BC was tested for correlation with the HRV recurrent quantification analysis (RQA) index Lmean, obtained from tachograms from the same ECG trace. BisQ is the result of adding BC values corresponding to the three frequency pairs exhibiting the highest correlation with Lmean. BisQ values were estimated for different groups of subjects: healthy persons, persons with arrhythmia, persons with epilepsy, and preterm neonates. ECG traces from persons with arrhythmia showed no significant differences in BisQ values respect to healthy persons, while persons with epilepsy and neonates showed higher BisQ values (p < 0.05 Mann-Whitney U-test). BisQ reflects nonlinear interactions at the level of sinus-and atrial-ventricular nodes, and most likely cardiorespiratory coupling as well. We expect that BisQ will allow for further exploration of cardiac nonlinear dynamics, complementing available HRV indices. |
| Databáze: | OpenAIRE |
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