Nickel/Briphos-Catalyzed Direct Transamidation of Unactivated Secondary Amides Using Trimethylsilyl Chloride
| Autor: | Subeen Yu, Maosheng Zhang, Taeil Shin, Hyunwoo Kim, Sunwoo Lee, Yuanzhi Xia |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Trimethylsilyl chloride
010405 organic chemistry Ligand Organic Chemistry chemistry.chemical_element Diglyme Manganese 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Nickel chemistry Physical and Theoretical Chemistry Benzamide |
| Zdroj: | Organic Letters. 20:7563-7566 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | Direct transamidation of secondary amides was developed via nickel catalysis. In the presence of trimethylsilyl chloride and manganese, Ni(diglyme)Cl2 with a Briphos ligand efficiently promoted the transamidation of N-aryl benzamide derivatives with primary amines to afford the corresponding secondary amides in moderate to good yields. Primary amines bearing electron-donating groups gave higher yields of the transamidation products. |
| Databáze: | OpenAIRE |
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