Increased IL-37 concentrations in patients with arterial calcification
| Autor: | Ling Liu, Dazhu Li, Yudong Peng, Kunwu Yu, Ying Huang, Yingzhong Lin, Kai Meng, Song Huang, Qingwei Ji, Qiutang Zeng, Xiaohong Min |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Vascular smooth muscle Clinical Biochemistry Inflammation Coronary Artery Disease 030204 cardiovascular system & hematology Biochemistry Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Aged Aged 80 and over business.industry Biochemistry (medical) Type 2 Diabetes Mellitus Interleukin General Medicine Middle Aged medicine.disease Arterial calcification 030104 developmental biology Diabetes Mellitus Type 2 Cardiology Alkaline phosphatase Immunohistochemistry Female medicine.symptom business Interleukin-1 |
| Zdroj: | Clinica Chimica Acta. 461:19-24 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2016.07.011 |
| Popis: | Background Our previous study indicates that IL-37 plays a critical role in both atherosclerosis and arterial calcification. However, whether IL-37 concentrations are significantly changed in patients with arterial calcification has not yet been investigated. Methods Anterior tibial arterial wall specimens were obtained from 8 patients with type 2 diabetes mellitus and 8 patients who experienced a traffic accident. IL-37 expression was measured by immunohistochemistry in the calcified and the normal samples. In addition, plasma IL-37 concentrations were measured in 75 patients with coronary artery calcification (CAC) and 50 patients without coronary artery calcification (NCAC). Results High concentrations of IL-37 were detected in calcified samples, whereas low concentrations of IL-37 were detected in the normal arteries. Macrophages and vascular smooth muscle cells were the main source of IL-37. P lasma IL-37 concentrations were significantly increased in CAC patients compared with NCAC patients. A correlation analysis showed that IL-37 was positively correlated with age, fasting glucose, alkaline phosphatase, IL-6, TNF-α, C-reactive protein and Agatston scores. Binary logistic regression analyses demonstrated that fasting glucose and IL-37 were independently associated with the presence of CAC. Conclusions Increased IL-37 concentrations are associated with the onset of arterial calcification. |
| Databáze: | OpenAIRE |
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