The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels
| Autor: | Hatice Işık, Yusuf Tanrıkulu, Nazife Alptekin, Hüsnü Alptekin, Emel Şahin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Levothyroxine lcsh:Medicine Umbilical cord Maternal hypothyroidism Pregnancy Internal medicine medicine Outpatient clinic Gebelik maternal hipotiroidi beyin kaynaklı nörotrofik faktör (BDNF) levotiroksin lcsh:R5-920 Fetus business.industry lcsh:R Gestational age medicine.disease maternal hypothyroidism medicine.anatomical_structure Endocrinology brain derived neurotrophic factor Cord blood lcsh:Medicine (General) business medicine.drug |
| Zdroj: | Volume: 43, Issue: 1 107-111 Dicle Tıp Dergisi Dicle Medical Journal, Vol 43, Iss 1, Pp 107-111 (2016) |
| ISSN: | 1308-9889 1300-2945 |
| Popis: | Objective: Brain derived neurotrophic factor (BDNF) is the most important neurotrophin, which helps the differentiation and growth of central and peripheral neurons, and facilitates synaptic transmission. In this study we aimed to investigate fetal cord BDNF levels of infants born from subclinical and clinical maternal hypothyroidism.Methods: This study was conducted on a total of 67 pregnant women who were followed up in Obstetrics and Gynecology outpatient clinics, 27 with maternal hypothyroidism and 40 age-parity matched healthy pregnants without hypothyroidism. Immediately after vaginal or cesarean delivery fetal cord blood samples were taken from these patients and BDNF levels were measured.Results: BDNF levels of infants born from pregnants with maternal hypothyroidism were significantly lower than the control group (23.3 ± 17.4 ng/dl and 50.7 ± 28.3 ng/dl respectively; p |
| Databáze: | OpenAIRE |
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