Lysine kinetics in preterm infants: the importance of enteral feeding
| Autor: | S R D van der Schoor, Peter J. Reeds, Frans Stellaard, J D L Wattimena, Hans A. Büller, J.B. van Goudoever, Pjj Sauer |
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| Přispěvatelé: | General Paediatrics, Pediatrics, Internal Medicine |
| Rok vydání: | 2004 |
| Předmět: |
Male
BIRTH-WEIGHT INFANTS Parenteral Nutrition medicine.medical_specialty Birth weight LEVEL Lysine CHILDREN BREATH TEST METABOLISM Biology OXIDATION complex mixtures Enteral administration Intestinal absorption First pass effect Enteral Nutrition Internal medicine medicine Humans AMINO-ACID-COMPOSITION Infant Nutritional Physiological Phenomena Essential amino acid chemistry.chemical_classification INTRAUTERINE GROWTH Infant Newborn Gastroenterology PROTEIN RESTRICTION Parenteral nutrition Endocrinology Intestinal Absorption chemistry Small Intestine LEUCINE KINETICS bacteria Female Dietary Proteins Splanchnic Oxidation-Reduction Infant Premature |
| Zdroj: | Gut, 53(1), 38-43. BMJ Publishing Group Gut, 53(1), 38-43. BMJ PUBLISHING GROUP Gut, 53, 38-43. BMJ Publishing Group |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.53.1.38 |
| Popis: | Introduction: Lysine is the first limiting essential amino acid in the diet of newborns. First pass metabolism by the intestine of dietary lysine has a direct effect on systemic availability. We investigated whether first pass lysine metabolism in the intestine is high in preterm infants, particularly at a low enteral intake. Patients and methods: Six preterm infants ( birth weight 0.9 ( 0.1) kg) were studied during two different periods: period A ( n = 6): 40% of intake administered enterally, 60% parenterally; lysine intake 92 ( 6) mumol/( kgxh); and period B ( n = 4): 100% enteral feeding; lysine intake 100 ( 3) mumol/( kgxh). Dual stable isotope tracer techniques were used to assess splanchnic and whole body lysine kinetics. Results: Fractional first pass lysine uptake by the intestine was significantly higher during partial enteral feeding ( period A 32 ( 10)% v period B 18 ( 7)%; p |
| Databáze: | OpenAIRE |
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