Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea

Autor: Serrano‐Pariente, J., Plaza, V., Soriano, J. B., Mayos, M., López‐Viña, A., Picado, C., Vigil, L., Sogo‐Sagardía, Ana, Crespo‐Lessmann, Astrid, Fortuna‐Gutiérrez, Ana M., González‐Gutiérrez, M. Victoria, Ortega‐Castillo, M. Pilar, Bardagí‐Forns, Santiago, Abeijón‐Insua, Benedicta, Somoza‐González, María, González‐Barcala, Francisco Javier, García‐Rivero, Juan Luis, González‐Martínez, Mónica, Sacristán‐Bou, Lirios, Trisán‐Alonso, Andrea, Martínez‐Moragón, Eva, Almonacid‐Sánchez, Carlos, Cisneros‐Serrano, Carolina, Mayoralas‐Alises, Sagrario, Figueroa‐Cézar, Milagros
Rok vydání: 2017
Předmět:
Male
evaluación del desenlace del paciente
medicine.medical_treatment
humanos
presión positiva continua en las vías respiratorias
Severity of Illness Index
Bronchial hyperreactivity
0302 clinical medicine
Quality of life
immune system diseases
Risk Factors
estudios prospectivos
Immunology and Allergy
Medicine
030212 general & internal medicine
Continuous positive airway pressure
Prospective Studies
mediana edad
anciano
Sleep Apnea
Obstructive
Continuous Positive Airway Pressure
resultado del tratamiento
adulto
Middle Aged
Respiratory Function Tests
asma
Obstructive sleep apnea syndrome
Treatment Outcome
Asthma Control Questionnaire
Anesthesia
Disease Progression
Original Article
Female
Adult
medicine.medical_specialty
Immunology
Airway Diseases
obstructive sleep apnea syndrome
pruebas de función respiratoria
03 medical and health sciences
progresión de la enfermedad
Internal medicine
Respiratory disturbance index
factores de riesgo
Humans
índice de gravedad de la enfermedad
Asthma
Aged
Intention-to-treat analysis
business.industry
asthma
medicine.disease
nervous system diseases
respiratory tract diseases
Obstructive sleep apnea
bronchial hyperreactivity
Patient Outcome Assessment
030228 respiratory system
quality of life
calidad de vida
Exhaled nitric oxide
ORIGINAL ARTICLES
business
Zdroj: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
ALLERGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Allergy
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
ISSN: 0105-4538
Popis: BackgroundContinuous positive airway pressure (CPAP) in asthma patients with concomitant obstructive sleep apnea syndrome (OSAS) seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies. MethodsProspective, multicenter study. We examined asthma outcomes after 6 months of CPAP in 99 adult asthma patients (mean age 57 years) with OSAS (respiratory disturbance index 20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire (ACQ) and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), respectively. Data were analyzed by intention-to-treat basis. ResultsThe mean SD score of the ACQ decreased from 1.39 +/- 0.91 at baseline to 1.0 +/- 0.78 at 6 months (P = 0.003), the percentage of patients with uncontrolled asthma from 41.4% to 17.2% (P = 0.006), and the percentage of patients with asthma attacks in the 6 months before and after treatment from 35.4% to 17.2% (P = 0.015). The score of the mAQLQ increased from 5.12 +/- 1.38 to 5.63 +/- 1.17 (P = 0.009). There were also significant improvements in symptoms of gastroesophageal reflux and rhinitis, bronchial reversibility, and exhaled nitric oxide values (all P < 0.05). No significant changes were observed in drug therapy for asthma or their comorbidities nor in the patients' weight. ConclusionsAsthma control (both actual and future risk), quality of life, and lung function improved after starting continuous positive airway pressure in asthmatics with moderate to severe obstructive sleep apnea syndrome.
This work was supported by a grant from the Spanish Society of Pneumology and Thoracic Surgery (SEPAR): 'Convocatoria Extraordinaria PII 2010-PII de Asma' (Barcelona, Spain, 2011).
Databáze: OpenAIRE
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