Increased Prevalence of Irritable Bowel Syndrome in Patients With Gastroesophageal Reflux
| Autor: | Joshua J. Ofman, Steven Fullerton, Phillip Hassard, Evelyn J. Chow, Federico Rossi, Henry C. Lin, Mark Pimentel |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Colonic Diseases Functional Disease Severity of Illness Index Gastroenterology Gastric Acid Esophagus Internal medicine Severity of illness Epidemiology Odds Ratio Prevalence Humans Medicine Irritable bowel syndrome business.industry Esophageal disease Reflux Odds ratio medicine.disease humanities digestive system diseases Gastroesophageal Reflux GERD Female Gastrointestinal Motility business |
| Zdroj: | Journal of Clinical Gastroenterology. 34:221-224 |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/00004836-200203000-00004 |
| Popis: | To determine the prevalence of irritable bowel syndrome (IBS) in subjects with gastroesophageal reflux disease (GERD) compared with non-GERD controls.Two hundred subjects were identified from a list of Cedars-Sinai Medical Foundation patients and gastroenterology motility practice subjects with and without a potential diagnosis of GERD. All subjects were then evaluated independently by two blinded physicians who were asked to identify subjects with GERD based on taking a history (gold standard). A follow-up questionnaire was later mailed to patients. This questionnaire included Rome I criteria for IBS. The prevalence of IBS was compared between GERD and non-GERD subjects. Finally, to further strengthen the method, a retrospective review of all subjects' charts was conducted to identify patients who had had 24-hour pH tests, and the prevalence of IBS was determined in this subgroup.Of the 200 subjects, 90 (45%) patients returned the questionnaire. After excluding subjects with IBD and incomplete questionnaires, there were 84 subjects (35 with GERD) included in the analysis. Of the 35 GERD subjects, 25 (71%) were Rome I criteria positive for IBS, whereas only 17 of the 49 (35%) non-GERD subjects had IBS (odds ratio = 54.7, CI = 1.7-13.5, p0.01). In 11 of the GERD subjects a 24-hour pH study was available and confirmed GERD. Of these 11 subjects, 7 (64%) met Rome I criteria for IBS.There is a higher prevalence of IBS in subjects with GERD compared with subjects without GERD. |
| Databáze: | OpenAIRE |
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