Thiamylal antagonizes the inhibitory effects of dorsal column stimulation on dorsal horn activities in humans
| Autor: | Yoshinaka Murai, Hideho Higashi, Eiichiro Tanaka, Koki Shimoji, Yasunori Okabe, Aya Yamada, Tatsuhiko Kano, Toshiyuki Tobita |
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| Rok vydání: | 2009 |
| Předmět: |
Epidural Space
Male Adolescent Action Potentials Pain Electric Stimulation Therapy Stimulation Pharmacology Inhibitory postsynaptic potential Somatosensory system Lumbar enlargement Evoked Potentials Somatosensory Thiamylal medicine Humans Wakefulness Child Electrodes Afferent Pathways Lumbar Vertebrae Dose-Response Relationship Drug Chemistry General Neuroscience Neural Inhibition General Medicine Spinal cord Antidromic Electrophysiology Posterior Horn Cells Lumbar Spinal Cord medicine.anatomical_structure Spinal Cord Anesthesia Female Spinal Nerve Roots Anesthetics Intravenous medicine.drug |
| Zdroj: | Neuroscience Research. 64:391-396 |
| ISSN: | 0168-0102 |
| Popis: | In humans, peripheral somatosensory information converges upon dorsal horn neurons in the spinal cord, which can be recorded from the dorsal epidural space as spinal cord potentials (SCPs) following segmental dorsal root stimulation (SS) employing epidural catheter electrodes. Antidromic action potentials and descending inhibition from the dorsolateral funiculus may contribute to SCPs following dorsal column stimulation (DCS). Effects of thiamylal (2.5–7.5 mg/kg, i.v.) on SCPs evoked by independent DCS or SS were compared with those evoked by simultaneous DCS and SS (DCS/SS). DCS- and SS-evoked SCPs recorded from the lumbar enlargement consisted of a sharp negative (N) followed by a slow positive (P) potential. Thiamylal induced dose-dependent increases in amplitude and duration of both N and P potentials evoked by DCS and SS, whether the responses were summed or evoked simultaneously. In awake subjects, N and P potentials produced by simultaneous DCS/SS were significantly smaller than the sum of independent responses. Thiamylal anesthesia antagonized this inhibition; responses to simultaneous DCS/SS were larger than the sum of independent responses. These results suggest that in wakefulness DCS inhibits dorsal horn neuron activity in the lumbar spinal cord, while thiamylal antagonizes DCS-induced inhibition in dose-dependent fashion. |
| Databáze: | OpenAIRE |
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