Nodular lymphoid hyperplasia of the bowel in primary hypogammaglobulinaemia: study of in vivo and in vitro lymphocyte function
| Autor: | Ballard J, G. Loewi, Kenwright S, G Slavin, M Shiner, A D Webster, A.J. Levi, G L Asherson |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Adolescent Lymphocyte Biology Lymphocyte Activation Leukocyte Count Immune system Antigen Agammaglobulinemia In vivo medicine Humans Lymphocytes Child Aged Hyperplasia Gastroenterology Germinal center Middle Aged medicine.disease Microscopy Electron Jejunum medicine.anatomical_structure Immunoglobulin M Immunology biology.protein Lymph Nodes Lymph Research Article |
| Zdroj: | Gut. 18:364-372 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.18.5.364 |
| Popis: | In vitro and in vivo lymphocyte function was studied in six patients with primary hypogammaglobulinaemia and nodular lymphoid hyperplasia (NLH) of the bowel. Lymphocyte transformation, numbers of circulating T and B lymphocytes, and delayed hypersensitivity skin tests did not significantly differ when compared with hypogammaglobulinaemic patients without NLH. However, patients with NLH had higher jejunal juice IgM concentrations and a tendency to higher serum IgM concentrations than those without NLH. The morphological features of NLH are similar to the germinal centres of lymph nodes but more closely resemble the follicle zone of Peyer's patches. These findings suggest that NLH represents a local immune response to antigens originating in the gut lumen. |
| Databáze: | OpenAIRE |
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