The temporal characterization of marrow lipids and adipocytes in a rabbit model of glucocorticoid-induced osteoporosis
| Autor: | Shixin Chang, Guanwu Li, Qi-Wen Chen, Zheng Xu, Jing-Zheng Fan, Ya-Nan Tian |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Magnetic Resonance Spectroscopy Osteoporosis chemistry.chemical_compound Bone Marrow Internal medicine Adipocyte Adipocytes medicine Animals Radiology Nuclear Medicine and imaging Glucocorticoids Cells Cultured Rupture Bone mineral business.industry Lipid metabolism Lipid Metabolism medicine.disease Endocrinology chemistry Adipogenesis Concomitant Female Histopathology Rabbits business Glucocorticoid medicine.drug |
| Zdroj: | Skeletal Radiology. 42:1235-1244 |
| ISSN: | 1432-2161 0364-2348 |
| DOI: | 10.1007/s00256-013-1659-7 |
| Popis: | To characterize the temporal changes in marrow lipids content and adipocytes in the development of glucocorticoid-induced osteoporosis (GIOP) in rabbits using MR spectroscopy. Twenty 20-week-old female rabbits were randomized to a control group and a GIOP group equally. Marrow lipids fraction and bone mineral density at the left proximal femur and L3–L4 vertebrae were measured by MR spectroscopy and dual-energy X-ray absorptiometry at week 0, 4, 8, and 12. Marrow adipocytes were quantitatively evaluated by histopathology. Marrow adiposity in the GIOP group showed a significant increase over time, with a variation of marrow lipids fraction (+35.9 %) at week 4 from baseline and it was maintained until week 12 (+75.2 %, p |
| Databáze: | OpenAIRE |
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