Lack of Probenecid Effect on Nonrenal Excretion of Ceftriaxone in Anephric Patients
| Autor: | Patricia R. Audet, Gene A. Gibson, John J. Carbone, Gail Morrison, Peter P. Soni, Indravadan H. Patel |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Pharmacology Time Factors Probenecid business.industry Ceftriaxone Middle Aged urologic and male genital diseases Crossover study Pharmacokinetic analysis Excretion Random Allocation Biliary excretion medicine Humans Kidney Failure Chronic Pharmacology (medical) business Chromatography High Pressure Liquid medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 30:449-453 |
| ISSN: | 0091-2700 |
| DOI: | 10.1002/j.1552-4604.1990.tb03484.x |
| Popis: | Probenecid has been shown to decrease renal and biliary excretion of organic acids. In a randomized crossover study, the effect of coadministered probenecid on nonrenal excretion of ceftriaxone was studied in six functionally anephric patients in whom ceftriaxone is eliminated exclusively by nonrenal or presumably by biliary excretion. Each patient received 0.5 g IV ceftriaxone without and with probenecid (0.5 g at 10 and 2 hours prior to ceftriaxone and 0.5 g q12h X 3 doses post ceftriaxone). Serial blood samples were collected over 48 hours and plasma analyzed for ceftriaxone by high performance liquid chromatography (HPLC). Pharmacokinetic analysis was based on a model-independent approach. Probenecid did not significantly affect the disposition of ceftriaxone in this study, thus suggesting that nonrenal excretion of ceftriaxone is not inhibited by probenecid. |
| Databáze: | OpenAIRE |
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