Dicarbonyls stimulate cellular protection systems in primary rat hepatocytes and show anti-inflammatory properties
| Autor: | Thierry Delatour, Timo Buetler, Hélia Latado, Alexandra Baumeyer |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Glycation End Products
Advanced Antioxidant medicine.drug_class medicine.medical_treatment Cellular detoxification Anti-Inflammatory Agents Polymerase Chain Reaction General Biochemistry Genetics and Molecular Biology Anti-inflammatory Cell Line History and Philosophy of Science Glycation Genes Reporter Detoxification medicine Animals RNA Messenger Cells Cultured Chemistry General Neuroscience TATA-Box Binding Protein Hydroquinones Rats Biochemistry Gene Expression Regulation Cell culture Phase II Detoxification Hepatocytes RNA Tumor necrosis factor alpha |
| Zdroj: | Annals of the New York Academy of Sciences. 1126 |
| ISSN: | 0077-8923 |
| Popis: | Advanced glycation endproducts (AGEs) and their precursor dicarbonyls are generally perceived as having adverse health effects. They are also considered to be initiators and promoters of disease and aging. However, proof for a causal relationship is lacking. On the other hand, it is known that AGEs and melanoidins possess beneficial properties, such as antioxidant and metal-chelating activities. Furthermore, some AGEs may stimulate the cellular detoxification system, generally known as the phase II drug metabolizing system. We show here that several reactive dicarbonyl intermediates have the capability to stimulate the cellular phase II detoxification systems in both a reporter cell line and primary rat hepatocytes. In addition, we demonstrate that dicarbonyls can attenuate the inflammatory signaling induced by tumor necrosis factor-alpha in a reporter cell system. |
| Databáze: | OpenAIRE |
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