Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes
| Autor: | Aritoshi Iida, Shiro Maeda, Yusuke Nakamura, Atsunori Kashiwagi, Tetsuya Babazono, Yasuhiko Iwamoto, Yoshihiro Kawamura, Tatsuhiko Tsunoda, Masafumi Matsuda, Masahito Imanishi, Akio Kanazawa, T. Iiizumi, Akihiro Sekine, Koichi Kawai, Tomoaki Fujioka, Yasutaka Tanaka, Ryuichi Kikkawa, Kohei Kaku, Ryuzo Kawamori |
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| Rok vydání: | 2005 |
| Předmět: |
Genotype
Endocrinology Diabetes and Metabolism Cellular differentiation Kruppel-Like Transcription Factors Single-nucleotide polymorphism Type 2 diabetes Biology Polymorphism Single Nucleotide Mice Reference Values Diabetes mellitus Odds Ratio Internal Medicine medicine Genetic predisposition Animals Humans Genetic Predisposition to Disease Gene Transcription factor Genetics Chromosome Mapping 3T3 Cells medicine.disease Introns DNA-Binding Proteins Diabetes Mellitus Type 2 Multigene Family TCF7L2 Transcription Factors |
| Zdroj: | Diabetologia. 48:1315-1322 |
| ISSN: | 1432-0428 0012-186X |
| Popis: | Although genetic susceptibility plays an important role in the pathogenesis of type 2 diabetes, most of the genes that influence susceptibility to type 2 diabetes have yet to be identified. Krüppel-like transcription factors are known to play important roles in development and cell differentiation, and have recently been implicated in the pathogenesis of type 2 diabetes. The present study aimed to examine the associations of single nucleotide polymorphisms (SNPs) in genes encoding members of the Krüppel-like-factor (KLF) family with type 2 diabetes in a large cohort of Japanese subjects.We genotyped 33 SNP loci found in 12 KLF genes in subjects with type 2 diabetes and in subjects from the general population using the PCR-Invader assay. We also examined the effects of the overexpression of KLF7 on adipogenesis in 3T3-L1 cells.We identified a significant association between an SNP in KLF7 and type 2 diabetes (A vs C: p=0.004 after Bonferroni's correction, odds ratio=1.59, 95% CI 1.27-2.00). The expression of Klf7 decreased in response to the differentiation of 3T3-L1 adipocytes, and the overexpression of KLF7 resulted in significant inhibition of adipogenesis in 3T3-L1 cells.These results indicate that the gene encoding KLF7 is a novel candidate for conferring genetic susceptibility to type 2 diabetes. |
| Databáze: | OpenAIRE |
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