Plasma prednisolone levels in man following administration in plain and enteric-coated forms
| Autor: | CG Wilson, JW Paterson, C S May |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Pharmacology
medicine.medical_specialty Time Factors Chemistry Prednisolone Absorption (skin) Plasma levels Intestinal absorption Bioavailability Kinetics Peak plasma Endocrinology Intestinal Absorption Internal medicine Plasma concentration medicine Humans Pharmacology (medical) Tablets Enteric-Coated Enteric coated Research Article Tablets medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 4:351-355 |
| ISSN: | 0306-5251 |
| DOI: | 10.1111/j.1365-2125.1977.tb00723.x |
| Popis: | 1 Prednisolone plasma levels were measured in seven patients by a competitive protein binding method after administration of prednisolone (20 mg) by mouth as plain or enteric-coated tablets. 2 The mean peak plasma prednisolone concentration after the enteric-coated preparation, 199 ng ml-1, was significantly lower than after the plain tablet, 268 ng ml-1, and occurred later, at 4.69 h compared with 1.72 h. The bioavailability of the two preparations was similar. 3 It is concluded that, although the plasma concentration versus time profiles are different, the absorption of prednisolone from plain and enteric-coated preparations is equal. |
| Databáze: | OpenAIRE |
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