Inhibitors of hepatitis C virus NS3·4A protease 2. Warhead SAR and optimization

Autor:	Ethan O'malley, Yunyi Wei, Yu-Ping Luong, John H. Van Drie, Lawrence F. Courtney, Scott L. Harbeson, Janos Pitlik, Kai Lin, Roger D. Tung, Young-Choon Moon, Shawn D. Britt, Chao Lin, Luc J. Farmer, B. Govinda Rao, John J. Court, Cynthia A. Gates, John A. Thomson, David D. Deininger, Robert B. Perni, Rhonda B. Levin
Rok vydání:	2004
Předmět:	Macrocyclic Compounds Serine Proteinase Inhibitors Stereochemistry Hepacivirus Hepatitis C virus medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Viral Nonstructural Proteins medicine.disease_cause Biochemistry Virus Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Peptide synthesis medicine Molecular Biology chemistry.chemical_classification Protease biology Serine Endopeptidases Organic Chemistry biology.organism_classification Thiazoles Enzyme chemistry Warhead Enzyme inhibitor Quinolines biology.protein Molecular Medicine Carbamates
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 14:1441-1446
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2004.01.022
Popis:	The α-ketoamide warhead (e.g., 15) was found to be a practical replacement for aliphatic aldehydes in a series of HCV NS3·4A protease inhibitors. Structure–activity relationships and prime side optimization are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56535e42d42b9915dbd7e2607e21e42a https://doi.org/10.1016/j.bmcl.2004.01.022 Zobrazit plný text záznamu Full Text from ScienceDirect