Architectural Patterns are a Relevant Morphologic Grading System for Clear Cell Renal Cell Carcinoma Prognosis Assessment

Autor:	Jérôme Verine, Guillaume Ploussard, Pierre Mongiat-Artus, Mary Nheb, Xavier Cathelineau, Dominique Prapotnich, François Desgrandchamps, Jean-Paul Feugeas, Delphine Colin
Rok vydání:	2018
Předmět:	Adult Male 0301 basic medicine Oncology medicine.medical_specialty Time Factors Lymphovascular invasion Biopsy Chromophobe cell World Health Organization Nephrectomy Disease-Free Survival Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Renal cell carcinoma Internal medicine medicine Carcinoma Humans Carcinoma Renal Cell Aged Neoplasm Staging Retrospective Studies Aged 80 and over Observer Variation business.industry Proportional hazards model Hazard ratio Reproducibility of Results Retrospective cohort study Middle Aged medicine.disease Kidney Neoplasms Clear cell renal cell carcinoma Treatment Outcome 030104 developmental biology 030220 oncology & carcinogenesis Female Surgery Neoplasm Grading Anatomy business
Zdroj:	American Journal of Surgical Pathology. 42:423-441
ISSN:	0147-5185
DOI:	10.1097/pas.0000000000001025
Popis:	We developed and validated an architecture-based grading for clear cell renal cell carcinoma (ccRCC) in an observational retrospective cohort study including 506 tumors (principal cohort, n=254; validation cohort, n=252). Study endpoints were disease-free survival (DFS) and cancer-specific survival (CSS). Relationships with outcome were analyzed using Harrell concordance index, time-dependent receiver operating characteristic curve, area under curve, and Cox regression model. An architecture-based grading was devised on positive likelihood ratio (LR+) for DFS at 50 months as follows: grade 1 (LR+
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5650e9dc99a4020919c90089968bed89 https://doi.org/10.1097/pas.0000000000001025 Zobrazit plný text záznamu