Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence
| Autor: | Rosa Cotugno, M. Zagari, Guglielmina Nadia Ranzani, Francesco Perri, Luigi Ricciardiello, Angelo Andriulli, Franco Bazzoli, M. Quitadamo, M. Di Candia, Cristian Bonvicini, Massimo Gennarelli, Annamaria Gentile, Francesca Cattaneo, Ada Piepoli |
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| Přispěvatelé: | Perri F., Piepoli A., Bonvicini C., Gentile A., Quitadamo M., Di Candia M., Cotugno R., Cattaneo F., Zagari M.R., Ricciardiello L., Gennarelli M., Bazzoli F., Ranzani G.N., Andriulli A. |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Linkage disequilibrium Adolescent Sialoglycoproteins Immunology Population Locus (genetics) Biochemistry Gastroenterology Risk Factors Stomach Neoplasms Internal medicine Genotype medicine Prevalence Immunology and Allergy SNP Humans education Molecular Biology Allele frequency Alleles Aged Aged 80 and over education.field_of_study Polymorphism Genetic biology Tumor Necrosis Factor-alpha Haplotype Hematology Cytokine Gastric cancer Helicobacter pylori Polymorphism Tumor necrosis factor α Helicobacter pylori Middle Aged biology.organism_classification Interleukin 1 Receptor Antagonist Protein Haplotypes Italy Female Interleukin-1 |
| Popis: | Polymorphisms of interleukin-1beta (IL-1beta), IL-1 receptor antagonist (IL1-RN), and tumor necrosis factor-alpha (TNF-alpha) genes are supposed to be key determinants of gastric cancer risk. Our aim was to study the association between these polymorphisms and gastric cancer in two areas characterized by high (Pavia/Bologna, North Italy) and low (San Giovanni Rotondo, South Italy) gastric cancer prevalence. Genomic DNA was obtained from 216 healthy donors and 98 gastric cancer patients from Pavia and Bologna, and 146 healthy donors and 86 gastric cancer patients from San Giovanni Rotondo. Two SNP in IL-1beta (-511 C/T) and TNF-alpha (-308 G/A) as well as the VNTR polymorphism of IL-1RN locus were studied. A significant linkage disequilibrium was found between IL-1beta -511 and IL-1RN. Genotype and allele frequencies at the IL-1beta, IL-1RN, and TNF-alpha loci in gastric cancer cases were not significantly different from controls. An epistatic effect between IL-1beta -511 and IL-1RN was found with the IL-1beta -511C/IL-1RN*2 haplotype conferring a significant protection against the intestinal-type of gastric cancer in the Southern population. In conclusion, IL-1beta, IL1-RN, and TNF-alpha genotypes are not associated with gastric cancer in Italian patients. An epistatic interrelationship between IL-1beta -511 and IL-1RN confers protection against gastric cancer in low-risk Italian population. |
| Databáze: | OpenAIRE |
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