Setomimycin as a potential molecule for COVID‑19 target: in silico approach and in vitro validation

Autor:	Ravi S. Manhas, Harshita Tiwari, Mateen Noor, Ajaz Ahmed, Jyoti Vishwakarma, Raja B. M. Tripathi, Ravishankar Ramachandran, Sreedhar Madishetti, Debaraj Mukherjee, Amit Nargotra, Asha Chaubey
Rok vydání:	2022
Předmět:	Inorganic Chemistry Organic Chemistry Drug Discovery General Medicine Physical and Theoretical Chemistry Molecular Biology Catalysis Information Systems
Zdroj:	Molecular diversity.
ISSN:	1573-501X
Popis:	COVID-19 pandemic caused by the SARS-CoV-2 virus has led to a worldwide crisis. In view of emerging variants time to time, there is a pressing need of effective COVID-19 therapeutics. Setomimycin, a rare tetrahydroanthracene antibiotic, remained unexplored for its therapeutic uses. Herein, we report our investigations on the potential of setomimycin as COVID-19 therapeutic. Pure setomimycin was isolated from Streptomyces sp. strain RA-WS2 from NW Himalayan region followed by establishing in silico as well as in vitro anti-SARS-CoV-2 property of the compound against SARS-CoV-2 main protease (M
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564fb16f1e03a52c3001bcd1e9c2e60a https://pubmed.ncbi.nlm.nih.gov/36036846 Zobrazit plný text záznamu Full text from SpringerLink