Detection of Anti-Phospholipid and Anti-DNA Antibodies and their Idiotypes in Newborns of Mothers with Anti-Phospholipid Syndrome and Sle
| Autor: | D Faden, N. Zurgil, J. Cohen, Y Shoenfeld, R. Bakimer, Guido Valesini, Margalit Lorber, Angela Tincani |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
idiotypes Offspring autoantibodies Enzyme-Linked Immunosorbent Assay anti-phosholipid syndrome 030204 cardiovascular system & hematology lupus antiphospholipid syndrome anti-dna antibodies anticardiolipin anti-cardiolipin autoimmunity 03 medical and health sciences 0302 clinical medicine Immunoglobulin Idiotypes Rheumatology Antiphospholipid syndrome immune system diseases medicine Humans Lupus Erythematosus Systemic 030203 arthritis & rheumatology Systemic lupus erythematosus biology business.industry Infant Newborn Autoantibody Antibody titer medicine.disease Myasthenia gravis Titer Antibodies Antinuclear Immunology Antibodies Antiphospholipid biology.protein Female Antibody business Immunity Maternally-Acquired |
| Zdroj: | Lupus. 2:233-237 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203393002001091 |
| Popis: | The titers, isotypes and idiotypes of antiphospholipid and anti-dsDNA antibodies were determined in seven pairs of mothers with antiphospholipid syndrome (APLS) and their offspring, in 11 pairs of SLE mothers and their matched infants and in seven respective pairs of healthy subjects. In addition, maternal as well as fetal sera were evaluated for the presence of anti-SSA (Ro), anti-SSB (La) and anti-70 kd RNP autoantibodies. In the sera from APLS patients, as well as in the sera from their offspring, the mean antibody titer of IgG aCL was found to be significantly higher then the corresponding value in the control group (P < 0.01). Highly significant increased titers of IgG anti-DNA antibodies were found in the sera of SLE mothers and their matched offspring (P < 0.0008). The prevalance of anti-SSA, anti-SSA, and anti-7OKd RNP antibodies was lower then that of antiphospholipid and anti-dsDNA antibodies. Only one of the respective offspring had increased levels of these antibodies. The quantity of maternal antibodies transferd to the fetus was depended on their concentration in the maternal circulation, as well as on their type and specificity. Follow-up of newborn sera showed a progressive decrease in the antiphospholipid antibody titers during 3 months. After 6 months it was undetected. Our results point to a transplacental transfer of aCL and anti-DNA antibodies, a phenomenon which is not necessarily associated with respective clinical manifestations, in contrast to the classical humoral mediated autoimmune diseases (e.g. myasthenia gravis). |
| Databáze: | OpenAIRE |
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