Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19

Autor:	Ram Babu Undi, Jason L. Larabee, Adrian Filiberti, Susanna Ulahannan, Sheeja Aravindan, Edana Stroberg, Lisa M. Barton, Eric J. Duval, Sanjay Mukhopadhyay, James C. Henthorn, Darrin Akins, Courtney W. Houchen, Mark M. Huycke, Naushad Ali
Rok vydání:	2022
Předmět:	SARS-CoV-2 Immunology Intracellular Signaling Peptides and Proteins COVID-19 Quinolones Microbiology Doublecortin-Like Kinases Virology Insect Science Leukocytes Mononuclear Calgranulin B Cytokines Humans Chemokines beta Catenin
Zdroj:	Journal of Virology. 96
ISSN:	1098-5514 0022-538X
Popis:	Host factors play critical roles in SARS-CoV-2 infection-associated pathology and the severity of COVID-19. In this study, we systematically analyzed the roles of SARS-CoV-2-induced host factors, doublecortin-like kinase 1 (DCLK1), and S100A9 in viral pathogenesis. In autopsied subjects with COVID-19 and pre-existing chronic liver disease, we observed high levels of DCLK1 and S100A9 expression and immunosuppressive (DCLK1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564e64dbda7a8c890a6c6de7127460b0 https://doi.org/10.1128/jvi.00967-22 Zobrazit plný text záznamu