Reasons for voriconazole prophylaxis discontinuation in allogeneic hematopoietic cell transplant recipients: A real-life paradigm
| Autor: | Miguel-Angel Perales, Shuk Ying Chan, Genovefa A. Papanicolaou, Rachel M Hughes, Kimberly Woo, Dionysios Neofytos |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Antifungal medicine.medical_specialty Antifungal Agents medicine.drug_class 03 medical and health sciences 0302 clinical medicine Risk Factors Invasive fungal infections Internal medicine medicine Humans Transplantation Homologous 030212 general & internal medicine Adverse effect Retrospective Studies Allogeneic hematopoietic cell transplant ddc:616 Voriconazole 0303 health sciences Hematopoietic cell 030306 microbiology business.industry Hematopoietic Stem Cell Transplantation Retrospective cohort study General Medicine Odds ratio Antibiotic Prophylaxis Middle Aged Transplant Recipients Discontinuation Treatment Outcome Infectious Diseases Female Original Article Chemical and Drug Induced Liver Injury business Invasive Fungal Infections Insurance coverage medicine.drug |
| Zdroj: | Medical Mycology, Vol. 58, No 8 (2020) pp. 1029-1036 Med Mycol |
| ISSN: | 1460-2709 1369-3786 |
| DOI: | 10.1093/mmy/myaa008 |
| Popis: | We sought to describe the clinical experience of voriconazole as primary antifungal prophylaxis (AFP) in allogeneic hematopoietic cell transplant recipients (allo-HCTr). This was a single-center retrospective study of adult allo-HCTr (1 January 2014 to 31 December 2016) who received ≥two doses of voriconazole-AFP. Voriconazole-AFP was started on day +7 post-HCT and continued at least through day +60 post-HCT, or longer as clinically indicated. We reviewed the rate, reasons, and risk factors of voriconazole-AFP discontinuation until day-100 post-HCT. A total of 327 patients were included. Voriconazole-AFP was continued for a median of 69 days (mean: 57.9; range 1, 100): for a median of 90 days (mean :84; range 2, 100) in 180/327 (55%) in the standard-of-care (SOC) group and 20 days (mean :25.6 ; range 1, 89; P-value |
| Databáze: | OpenAIRE |
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