Combination of oral terbinafine and topical ciclopirox compared to oral terbinafine for the treatment of onychomycosis
| Autor: | Shemer Avner, Nathansohn Nir, Trau Henri |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Antifungal Agents Combination therapy Pyridones Administration Topical Administration Oral Dermatology Naphthalenes law.invention Pharmacotherapy Randomized controlled trial Oral administration law Onychomycosis medicine Humans Terbinafine Mycosis Ciclopirox business.industry Middle Aged medicine.disease Treatment Outcome Nail disease Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Journal of Dermatological Treatment. 16:327-330 |
| ISSN: | 1471-1753 0954-6634 |
| Popis: | Treatment of onychomycosis has recently been enhanced by the introduction of combination therapies.To evaluate the efficacy of a combination therapy of ciclopirox nail lacquer and oral terbinafine compared to oral terbinafine monotherapy for the treatment of onychomycosis caused by dermatophytes.Eighty patients with onychomycosis were randomly assigned to receive either oral terbinafine 250 mg/day for 16 weeks or a combination of oral terbinafine 250 mg/day for 16 weeks and topical ciclopirox nail lacquer once daily for 9 months. Both groups were followed up for 9 months from start of treatment.After 9 months of treatment, the mycological cure rates were 22/34 (64.7%) for the terbinafine-only group and 30/34 (88.2%) for the combination therapy group (p0.05). No significant difference was noted in the complete cure rate.Combination therapy of oral terbinafine and ciclopirox nail lacquer is a safe and more effective treatment for onychomycosis than terbinafine alone, especially in younger patients and in shorter-duration onychomycosis. |
| Databáze: | OpenAIRE |
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